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TargetMitogen-activated protein kinase 1
LigandBDBM157706
Substrate/Competitorn/a
Meas. Tech.IMAP-FP Assay
IC50 0.1837±n/a nM
Citation Lim, JKelley, EHMethot, JLZhou, HPetrocchi, AMansoor, UFFischer, CO'Boyle, BGuerin, DJBienstock, CEBoyce, CWDaniels, MHFalcone, DFerguson, RDFevrier, SHuang, XLipford, KASloman, DLWilson, KZhou, WWitter, DMaletic, MMSiliphaivanh, P Compounds that are ERK inhibitors US Patent US9023865 Publication Date 5/5/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase 1
Name:Mitogen-activated protein kinase 1
Synonyms:ERK2 | ERT1 | Extracellular signal-regulated kinase 2 | Extracellular signal-regulated kinase 2 (ERK-2) | Extracellular signal-regulated kinase 2 (ERK2) | MAP Kinase 2/ERK2 | MAPK 2 | MAPK1 | MK01_HUMAN | Mitogen activated kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK-2) | Mitogen-activated protein kinase 1 (ERK2) | Mitogen-activated protein kinase 2 | PRKM1 | PRKM2 | p42-MAPK
Type:Ser/Thr Protein Kinase
Mol. Mass.:41392.76
Organism:Homo sapiens (Human)
Description:P28482
Residue:360
Sequence:
MAAAAAAGAGPEMVRGQVFDVGPRYTNLSYIGEGAYGMVCSAYDNVNKVRVAIKKISPFE
HQTYCQRTLREIKILLRFRHENIIGINDIIRAPTIEQMKDVYIVQDLMETDLYKLLKTQH
LSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLLNTTCDLKICDFGLARVADPDHDH
TGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHI
LGILGSPSQEDLNCIINLKARNYLLSLPHKNKVPWNRLFPNADSKALDLLDKMLTFNPHK
RIEVEQALAHPYLEQYYDPSDEPIAEAPFKFDMELDDLPKEKLKELIFEETARFQPGYRS
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  Blast E-value cutoff:
BDBM157706
n/a
NameBDBM157706
Synonyms:US9023865, 547
TypeSmall organic molecule
Emp. Form.C21H19FN6O2
Mol. Mass.406.413
SMILESCOC[C@@H](NC(=O)Nc1ncc2c(n[nH]c2c1F)-c1ccncc1)c1ccccc1 |r|
Structure
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