Reaction Details | |||
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Target | Mitogen-activated protein kinase kinase kinase 14 | ||
Ligand | BDBM158743 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
Ki | 0.31±n/a nM | ||
Comments | extracted | ||
Citation | Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase 14 | |||
Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
Type: | Protein | ||
Mol. Mass.: | 104059.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99558 | ||
Residue: | 947 | ||
Sequence: |
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BDBM158743 | |||
n/a | |||
Name | BDBM158743 | ||
Synonyms: | US9034866, 218 | ||
Type | Small organic molecule | ||
Emp. Form. | C25H23FN4O3 | ||
Mol. Mass. | 446.4735 | ||
SMILES | Cc1cc(no1)[C@](C)(O)C#Cc1cc2-c3nc(C(N)=O)c(C4CC4)n3C3CC(C3)c2cc1F |r,wU:6.8,wD:6.9,(-9.15,-.72,;-7.82,-1.49,;-6.57,-.59,;-5.32,-1.49,;-5.8,-2.96,;-7.34,-2.96,;-3.99,-.72,;-3.22,-2.06,;-5.32,.05,;-2.66,.05,;-1.32,.82,;.01,1.59,;1.34,.82,;2.68,1.59,;3.88,.63,;3.74,-.91,;5.16,-1.51,;5.56,-3,;4.47,-4.09,;7.05,-3.4,;6.17,-.35,;7.66,-.75,;8.75,-1.84,;9.15,-.35,;5.38,.97,;6.05,2.36,;5.38,3.75,;3.88,4.09,;4.56,2.76,;2.68,3.13,;1.34,3.9,;.01,3.13,;-1.32,3.9,)| | ||
Structure |