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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158773 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 0.5±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
| ||
| BDBM158773 | |||
| n/a | |||
| Name | BDBM158773 | ||
| Synonyms: | US9034866, 248 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C22H24FN3O3 | ||
| Mol. Mass. | 397.4427 | ||
| SMILES | CC(C)(O)C#Cc1cc2-c3nc(C(N)=O)c(n3C3CC(C3)c2cc1F)C(C)(C)O |(7.36,.36,;6.03,1.13,;7.36,1.9,;5.63,2.62,;4.7,.36,;3.36,-.41,;2.03,-1.18,;.63,-.53,;-.63,-1.42,;-1.91,-.57,;-1.91,.97,;-3.38,1.44,;-3.78,2.93,;-5.26,3.33,;-2.69,4.02,;-4.28,.2,;-3.38,-1.05,;-3.92,-2.49,;-3.13,-3.81,;-1.6,-4.02,;-2.43,-2.26,;-.49,-2.96,;.91,-3.6,;2.17,-2.72,;3.5,-3.49,;-5.82,.2,;-6.59,-1.14,;-7.36,.2,;-6.59,1.53,)| | ||
| Structure | 
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