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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Mitogen-activated protein kinase kinase kinase 14 | ||
| Ligand | BDBM158775 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Inhibition Assay | ||
| pH | 7.2±n/a | ||
| Ki | 0.12±n/a nM | ||
| Comments | extracted | ||
| Citation |  Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Mitogen-activated protein kinase kinase kinase 14 | |||
| Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
| Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
| Type: | Protein | ||
| Mol. Mass.: | 104059.50 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q99558 | ||
| Residue: | 947 | ||
| Sequence: |
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| BDBM158775 | |||
| n/a | |||
| Name | BDBM158775 | ||
| Synonyms: | US9034866, 250 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C21H22N4O3 | ||
| Mol. Mass. | 378.4244 | ||
| SMILES | CNC(=O)c1c(nc2-c3cc(ccc3C3CC(C3)n12)C#CC(C)(C)O)C(N)=O |(-7.71,-.66,;-6.22,-1.06,;-5.45,.27,;-6.22,1.6,;-3.91,.27,;-3,1.52,;-1.54,1.04,;-1.54,-.5,;-.3,-1.59,;1.04,-.82,;2.37,-1.59,;2.37,-3.13,;1.04,-3.9,;-.3,-3.13,;-1.5,-4.09,;-3,-3.75,;-3.67,-2.36,;-2.06,-2.68,;-3,-.98,;3.7,-.82,;5.04,-.05,;6.37,.72,;7.71,-.05,;7.71,1.49,;6.37,2.26,;-3.4,3,;-4.89,3.4,;-2.31,4.09,)| | ||
| Structure | 
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