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TargetMitogen-activated protein kinase kinase kinase 14
LigandBDBM158893
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.2±n/a
Ki 0.4±n/a nM
Commentsextracted
Citation Staben, SCastanedo, GMontalbetti, CAFeng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 14
Name:Mitogen-activated protein kinase kinase kinase 14
Synonyms:HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK
Type:Protein
Mol. Mass.:104059.50
Organism:Homo sapiens (Human)
Description:Q99558
Residue:947
Sequence:
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
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BDBM158893
n/a
NameBDBM158893
Synonyms:US9034866, 368
TypeSmall organic molecule
Emp. Form.C22H21FN4O3
Mol. Mass.408.4255
SMILESCNC(=O)c1c(nc2-c3cc(C#CC4(O)CCC4)c(F)cc3C3CC(C3)n12)C(N)=O |(-8.06,.06,;-6.57,-.34,;-5.48,.75,;-5.88,2.24,;-3.99,.35,;-2.98,1.51,;-1.56,.91,;-1.7,-.63,;-.5,-1.59,;.84,-.82,;2.17,-1.59,;3.5,-.82,;4.84,-.05,;6.17,.72,;4.84,1.49,;7.66,.32,;8.06,1.81,;6.57,2.21,;2.17,-3.13,;3.5,-3.9,;.84,-3.9,;-.5,-3.13,;-1.7,-4.09,;-3.2,-3.75,;-3.87,-2.36,;-2.26,-2.36,;-3.2,-.97,;-3.38,3,;-2.29,4.09,;-4.87,3.4,)|
Structure
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