Reaction Details | |||
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Target | Mitogen-activated protein kinase kinase kinase 14 | ||
Ligand | BDBM158893 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
Ki | 0.4±n/a nM | ||
Comments | extracted | ||
Citation | Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase 14 | |||
Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
Type: | Protein | ||
Mol. Mass.: | 104059.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99558 | ||
Residue: | 947 | ||
Sequence: |
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BDBM158893 | |||
n/a | |||
Name | BDBM158893 | ||
Synonyms: | US9034866, 368 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H21FN4O3 | ||
Mol. Mass. | 408.4255 | ||
SMILES | CNC(=O)c1c(nc2-c3cc(C#CC4(O)CCC4)c(F)cc3C3CC(C3)n12)C(N)=O |(-8.06,.06,;-6.57,-.34,;-5.48,.75,;-5.88,2.24,;-3.99,.35,;-2.98,1.51,;-1.56,.91,;-1.7,-.63,;-.5,-1.59,;.84,-.82,;2.17,-1.59,;3.5,-.82,;4.84,-.05,;6.17,.72,;4.84,1.49,;7.66,.32,;8.06,1.81,;6.57,2.21,;2.17,-3.13,;3.5,-3.9,;.84,-3.9,;-.5,-3.13,;-1.7,-4.09,;-3.2,-3.75,;-3.87,-2.36,;-2.26,-2.36,;-3.2,-.97,;-3.38,3,;-2.29,4.09,;-4.87,3.4,)| | ||
Structure |