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TargetMitogen-activated protein kinase kinase kinase 14
LigandBDBM158907
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.2±n/a
Ki 0.5±n/a nM
Commentsextracted
Citation Staben, SCastanedo, GMontalbetti, CAFeng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015
More Info.:Get all data from this article,  Assay Method
 
Mitogen-activated protein kinase kinase kinase 14
Name:Mitogen-activated protein kinase kinase kinase 14
Synonyms:HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK
Type:Protein
Mol. Mass.:104059.50
Organism:Homo sapiens (Human)
Description:Q99558
Residue:947
Sequence:
MAVMEMACPGAPGSAVGQQKELPKAKEKTPPLGKKQSSVYKLEAVEKSPVFCGKWEILND
VITKGTAKEGSEAGPAAISIIAQAECENSQEFSPTFSERIFIAGSKQYSQSESLDQIPNN
VAHATEGKMARVCWKGKRRSKARKKRKKKSSKSLAHAGVALAKPLPRTPEQESCTIPVQE
DESPLGAPYVRNTPQFTKPLKEPGLGQLCFKQLGEGLRPALPRSELHKLISPLQCLNHVW
KLHHPQDGGPLPLPTHPFPYSRLPHPFPFHPLQPWKPHPLESFLGKLACVDSQKPLPDPH
LSKLACVDSPKPLPGPHLEPSCLSRGAHEKFSVEEYLVHALQGSVSSGQAHSLTSLAKTW
AARGSRSREPSPKTEDNEGVLLTEKLKPVDYEYREEVHWATHQLRLGRGSFGEVHRMEDK
QTGFQCAVKKVRLEVFRAEELMACAGLTSPRIVPLYGAVREGPWVNIFMELLEGGSLGQL
VKEQGCLPEDRALYYLGQALEGLEYLHSRRILHGDVKADNVLLSSDGSHAALCDFGHAVC
LQPDGLGKSLLTGDYIPGTETHMAPEVVLGRSCDAKVDVWSSCCMMLHMLNGCHPWTQFF
RGPLCLKIASEPPPVREIPPSCAPLTAQAIQEGLRKEPIHRVSAAELGGKVNRALQQVGG
LKSPWRGEYKEPRHPPPNQANYHQTLHAQPRELSPRAPGPRPAEETTGRAPKLQPPLPPE
PPEPNKSPPLTLSKEESGMWEPLPLSSLEPAPARNPSSPERKATVPEQELQQLEIELFLN
SLSQPFSLEEQEQILSCLSIDSLSLSDDSEKNPSKASQSSRDTLSSGVHSWSSQAEARSS
SWNMVLARGRPTDTPSYFNGVKVQIQSLNGEHLHIREFHRVKVGDIATGISSQIPAAAFS
LVTKDGQPVRYDMEVPDSGIDLQCTLAPDGSFAWSWRVKHGQLENRP
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  Blast E-value cutoff:
BDBM158907
n/a
NameBDBM158907
Synonyms:US9034866, 382
TypeSmall organic molecule
Emp. Form.C22H21FN4O3
Mol. Mass.408.4255
SMILESCN1CC[C@](O)(C#Cc2cc3-c4nc(C(N)=O)n(C)c4C4CC(C4)c3cc2F)C1=O |r,wU:4.4,wD:4.5,(3.62,4.26,;4.39,2.92,;5.93,2.92,;6.4,1.46,;5.16,.55,;6.49,-.22,;3.82,-.22,;2.49,-.99,;1.16,-1.76,;-.18,-.99,;-1.51,-1.76,;-2.71,-.8,;-2.58,.74,;-3.99,1.34,;-4.39,2.83,;-3.3,3.92,;-5.88,3.23,;-5,.18,;-6.49,.58,;-4.22,-1.14,;-4.88,-2.53,;-4.22,-3.91,;-2.71,-4.26,;-3.33,-2.82,;-1.51,-3.3,;-.18,-4.07,;1.16,-3.3,;2.49,-4.07,;3.91,1.46,;2.58,.69,)|
Structure
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