Reaction Details | |||
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Target | Mitogen-activated protein kinase kinase kinase 14 | ||
Ligand | BDBM158907 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Inhibition Assay | ||
pH | 7.2±n/a | ||
Ki | 0.5±n/a nM | ||
Comments | extracted | ||
Citation | Staben, S; Castanedo, G; Montalbetti, CA; Feng, J Tricyclic compounds and methods of use therefor US Patent US9034866 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Mitogen-activated protein kinase kinase kinase 14 | |||
Name: | Mitogen-activated protein kinase kinase kinase 14 | ||
Synonyms: | HsNIK | M3K14_HUMAN | MAP3K14 | NF-kappa-beta-inducing kinase | NF-kappa-beta-inducing kinase (NF-kB) | NIK | Serine/threonine-protein kinase NIK | ||
Type: | Protein | ||
Mol. Mass.: | 104059.50 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q99558 | ||
Residue: | 947 | ||
Sequence: |
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BDBM158907 | |||
n/a | |||
Name | BDBM158907 | ||
Synonyms: | US9034866, 382 | ||
Type | Small organic molecule | ||
Emp. Form. | C22H21FN4O3 | ||
Mol. Mass. | 408.4255 | ||
SMILES | CN1CC[C@](O)(C#Cc2cc3-c4nc(C(N)=O)n(C)c4C4CC(C4)c3cc2F)C1=O |r,wU:4.4,wD:4.5,(3.62,4.26,;4.39,2.92,;5.93,2.92,;6.4,1.46,;5.16,.55,;6.49,-.22,;3.82,-.22,;2.49,-.99,;1.16,-1.76,;-.18,-.99,;-1.51,-1.76,;-2.71,-.8,;-2.58,.74,;-3.99,1.34,;-4.39,2.83,;-3.3,3.92,;-5.88,3.23,;-5,.18,;-6.49,.58,;-4.22,-1.14,;-4.88,-2.53,;-4.22,-3.91,;-2.71,-4.26,;-3.33,-2.82,;-1.51,-3.3,;-.18,-4.07,;1.16,-3.3,;2.49,-4.07,;3.91,1.46,;2.58,.69,)| | ||
Structure |