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TargetSodium/glucose cotransporter 2
LigandBDBM159537
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.4±n/a
Temperature310.15±n/a K
IC50 0.574±n/a nM
Commentsextracted
Citation Choi, SSong, KSLee, SHKim, MJSeo, HJPark, EKong, YPark, SOKang, HJung, MELee, KKim, HJLee, JSLee, MWKim, MHong, DHKang, M Diphenylmethane derivatives as SGLT2 inhibitors US Patent US9034921 Publication Date 5/19/2015
More Info.:Get all data from this article,  Assay Method
 
Sodium/glucose cotransporter 2
Name:Sodium/glucose cotransporter 2
Synonyms:Na(+)/glucose cotransporter 2 | SC5A2_HUMAN | SGLT2 | SLC5A2 | Sodium-Dependent Glucose Cotransporter 2 (SGLT2) | Sodium/glucose cotransporter 1 (SGLT1) | Solute carrier family 5 member 2
Type:Protein
Mol. Mass.:72902.00
Organism:Homo sapiens (Human)
Description:P31639
Residue:672
Sequence:
MEEHTEAGSAPEMGAQKALIDNPADILVIAAYFLLVIGVGLWSMCRTNRGTVGGYFLAGR
SMVWWPVGASLFASNIGSGHFVGLAGTGAASGLAVAGFEWNALFVVLLLGWLFAPVYLTA
GVITMPQYLRKRFGGRRIRLYLSVLSLFLYIFTKISVDMFSGAVFIQQALGWNIYASVIA
LLGITMIYTVTGGLAALMYTDTVQTFVILGGACILMGYAFHEVGGYSGLFDKYLGAATSL
TVSEDPAVGNISSFCYRPRPDSYHLLRHPVTGDLPWPALLLGLTIVSGWYWCSDQVIVQR
CLAGKSLTHIKAGCILCGYLKLTPMFLMVMPGMISRILYPDEVACVVPEVCRRVCGTEVG
CSNIAYPRLVVKLMPNGLRGLMLAVMLAALMSSLASIFNSSSTLFTMDIYTRLRPRAGDR
ELLLVGRLWVVFIVVVSVAWLPVVQAAQGGQLFDYIQAVSSYLAPPVSAVFVLALFVPRV
NEQGAFWGLIGGLLMGLARLIPEFSFGSGSCVQPSACPAFLCGVHYLYFAIVLFFCSGLL
TLTVSLCTAPIPRKHLHRLVFSLRHSKEEREDLDADEQQGSSLPVQNGCPESAMEMNEPQ
APAPSLFRQCLLWFCGMSRGGVGSPPPLTQEEAAAAARRLEDISEDPSWARVVNLNALLM
MAVAVFLWGFYA
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BDBM159537
n/a
NameBDBM159537
Synonyms:US9034921, E180
TypeSmall organic molecule
Emp. Form.C24H27ClO6
Mol. Mass.446.921
SMILESCC(=C)c1ccc(Cc2cc([C@@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3O)c3CCOc3c2Cl)cc1 |r|
Structure
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