Search and Browse
Download
Enter Data
| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM159755 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 16±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brown, MF; Fenwick, AE; Flanagan, ME; Gonzales, A; Johnson, TA; Kaila, N; Mitton-Fry, MJ; Strohbach, JW; TenBrink, RE; Trzupek, JD; Unwalla, RJ; Vazquez, ML; Parikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM159755 | |||
| n/a | |||
| Name | BDBM159755 | ||
| Synonyms: | US10966980, Example 7B | US9035074, 7B | ||
| Type | Small organic molecule | ||
| Emp. Form. | C18H24N6O2S | ||
| Mol. Mass. | 388.487 | ||
| SMILES | CN([C@@H]1C[C@@H](C1)NS(=O)(=O)[C@H]1C[C@](C)(CC#N)C1)c1ncnc2[nH]ccc12 |r,wU:12.14,wD:2.1,4.6,10.10,12.13,(-5.49,3.28,;-4.4,2.19,;-2.91,2.59,;-2.14,3.92,;-.81,3.15,;-1.58,1.82,;.68,3.55,;1.77,2.46,;3.26,2.86,;1.37,.97,;2.86,1.37,;2.86,-.17,;4.4,-.17,;5.73,.6,;5.49,-1.26,;4.72,-2.59,;3.95,-3.92,;4.4,1.37,;-4.4,.65,;-5.73,-.12,;-5.73,-1.66,;-4.4,-2.43,;-3.06,-1.66,;-1.6,-2.14,;-.69,-.89,;-1.6,.36,;-3.06,-.12,)| | ||
| Structure | 
| ||