Reaction Details | |||
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Target | Tyrosine-protein kinase JAK1 | ||
Ligand | BDBM159760 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 6±n/a nM | ||
Comments | extracted | ||
Citation | Brown, MF; Fenwick, AE; Flanagan, ME; Gonzales, A; Johnson, TA; Kaila, N; Mitton-Fry, MJ; Strohbach, JW; TenBrink, RE; Trzupek, JD; Unwalla, RJ; Vazquez, ML; Parikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Tyrosine-protein kinase JAK1 | |||
Name: | Tyrosine-protein kinase JAK1 | ||
Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
Type: | Protein | ||
Mol. Mass.: | 133293.73 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P23458 | ||
Residue: | 1154 | ||
Sequence: |
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BDBM159760 | |||
n/a | |||
Name | BDBM159760 | ||
Synonyms: | US10966980, Example 12 | US9035074, 12 | ||
Type | Small organic molecule | ||
Emp. Form. | C16H21F2N5O2S | ||
Mol. Mass. | 385.432 | ||
SMILES | CN([C@@H]1C[C@@H](C1)NS(=O)(=O)CC1CC(F)(F)C1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.6,(-5.73,.84,;-4.4,.07,;-3.06,.84,;-3.06,2.38,;-1.52,2.38,;-1.52,.84,;-.44,3.47,;1.05,3.07,;1.45,4.55,;.65,1.58,;2.54,2.67,;3.31,1.33,;2.91,-.15,;4.4,-.55,;5.73,-1.32,;3.63,-1.89,;4.8,.94,;-4.4,-1.47,;-5.73,-2.24,;-5.73,-3.78,;-4.4,-4.55,;-3.06,-3.78,;-1.6,-4.26,;-.69,-3.01,;-1.6,-1.77,;-3.06,-2.24,)| | ||
Structure |