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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM159773 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 17±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brown, MF; Fenwick, AE; Flanagan, ME; Gonzales, A; Johnson, TA; Kaila, N; Mitton-Fry, MJ; Strohbach, JW; TenBrink, RE; Trzupek, JD; Unwalla, RJ; Vazquez, ML; Parikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM159773 | |||
| n/a | |||
| Name | BDBM159773 | ||
| Synonyms: | US10966980, Example 27 | US9035074, 27 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H21N7O2S | ||
| Mol. Mass. | 387.459 | ||
| SMILES | CN([C@@H]1C[C@@H](C1)NS(=O)(=O)N1C[C@@H]2C[C@@]2(C1)C#N)c1ncnc2[nH]ccc12 |r,wU:12.13,wD:2.1,4.6,14.18,(-6.58,1.48,;-5.25,.71,;-3.92,1.48,;-3.52,2.97,;-2.03,2.57,;-2.43,1.09,;-.7,3.34,;.64,2.57,;-.13,1.24,;1.41,3.91,;1.97,1.8,;2.13,.27,;3.64,-.05,;5.18,-.05,;4.41,1.28,;3.38,2.43,;5.5,2.37,;6.58,3.46,;-5.25,-.83,;-6.58,-1.6,;-6.58,-3.14,;-5.25,-3.91,;-3.92,-3.14,;-2.45,-3.61,;-1.55,-2.37,;-2.45,-1.12,;-3.92,-1.6,)| | ||
| Structure | 
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