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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Tyrosine-protein kinase JAK1 | ||
| Ligand | BDBM159775 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Enzyme Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 9±n/a nM | ||
| Comments | extracted | ||
| Citation |  Brown, MF; Fenwick, AE; Flanagan, ME; Gonzales, A; Johnson, TA; Kaila, N; Mitton-Fry, MJ; Strohbach, JW; TenBrink, RE; Trzupek, JD; Unwalla, RJ; Vazquez, ML; Parikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Tyrosine-protein kinase JAK1 | |||
| Name: | Tyrosine-protein kinase JAK1 | ||
| Synonyms: | JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1 | ||
| Type: | Protein | ||
| Mol. Mass.: | 133293.73 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | P23458 | ||
| Residue: | 1154 | ||
| Sequence: |
| ||
| BDBM159775 | |||
| n/a | |||
| Name | BDBM159775 | ||
| Synonyms: | US10966980, Example 25 | US9035074, 25 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C17H23F2N5O2S | ||
| Mol. Mass. | 399.459 | ||
| SMILES | CN([C@@H]1C[C@H](CS(=O)(=O)N2CCC(F)(F)CC2)C1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.4,(-5.79,-.25,;-4.45,-1.02,;-3.12,-.25,;-2.72,1.23,;-1.23,.84,;.1,1.61,;1.43,.84,;.34,-.25,;2.52,-.25,;2.52,1.93,;4.01,1.53,;5.1,2.62,;4.7,4.1,;5.79,5.19,;4.7,5.64,;3.21,4.5,;2.12,3.41,;-1.63,-.65,;-4.45,-2.56,;-5.79,-3.33,;-5.79,-4.87,;-4.45,-5.64,;-3.12,-4.87,;-1.66,-5.35,;-.75,-4.1,;-1.66,-2.86,;-3.12,-3.33,)| | ||
| Structure | 
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