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TargetTyrosine-protein kinase JAK1
LigandBDBM159781
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 14±n/a nM
Commentsextracted
Citation Brown, MFFenwick, AEFlanagan, MEGonzales, AJohnson, TAKaila, NMitton-Fry, MJStrohbach, JWTenBrink, RETrzupek, JDUnwalla, RJVazquez, MLParikh, MD Pyrrolo[2,3-D]pyrimidine derivatives US Patent US9035074 Publication Date 5/19/2015
More Info.:Get all data from this article,  Assay Method
 
Tyrosine-protein kinase JAK1
Name:Tyrosine-protein kinase JAK1
Synonyms:JAK-1 | JAK1 | JAK1A | JAK1B | JAK1_HUMAN | Janus kinase 1 | Janus kinase 1 (JAK1) | Janus kinase 1 JAK1
Type:Protein
Mol. Mass.:133293.73
Organism:Homo sapiens (Human)
Description:P23458
Residue:1154
Sequence:
MQYLNIKEDCNAMAFCAKMRSSKKTEVNLEAPEPGVEVIFYLSDREPLRLGSGEYTAEEL
CIRAAQACRISPLCHNLFALYDENTKLWYAPNRTITVDDKMSLRLHYRMRFYFTNWHGTN
DNEQSVWRHSPKKQKNGYEKKKIPDATPLLDASSLEYLFAQGQYDLVKCLAPIRDPKTEQ
DGHDIENECLGMAVLAISHYAMMKKMQLPELPKDISYKRYIPETLNKSIRQRNLLTRMRI
NNVFKDFLKEFNNKTICDSSVSTHDLKVKYLATLETLTKHYGAEIFETSMLLISSENEMN
WFHSNDGGNVLYYEVMVTGNLGIQWRHKPNVVSVEKEKNKLKRKKLENKHKKDEEKNKIR
EEWNNFSYFPEITHIVIKESVVSINKQDNKKMELKLSSHEEALSFVSLVDGYFRLTADAH
HYLCTDVAPPLIVHNIQNGCHGPICTEYAINKLRQEGSEEGMYVLRWSCTDFDNILMTVT
CFEKSEQVQGAQKQFKNFQIEVQKGRYSLHGSDRSFPSLGDLMSHLKKQILRTDNISFML
KRCCQPKPREISNLLVATKKAQEWQPVYPMSQLSFDRILKKDLVQGEHLGRGTRTHIYSG
TLMDYKDDEGTSEEKKIKVILKVLDPSHRDISLAFFEAASMMRQVSHKHIVYLYGVCVRD
VENIMVEEFVEGGPLDLFMHRKSDVLTTPWKFKVAKQLASALSYLEDKDLVHGNVCTKNL
LLAREGIDSECGPFIKLSDPGIPITVLSRQECIERIPWIAPECVEDSKNLSVAADKWSFG
TTLWEICYNGEIPLKDKTLIEKERFYESRCRPVTPSCKELADLMTRCMNYDPNQRPFFRA
IMRDINKLEEQNPDIVSEKKPATEVDPTHFEKRFLKRIRDLGEGHFGKVELCRYDPEGDN
TGEQVAVKSLKPESGGNHIADLKKEIEILRNLYHENIVKYKGICTEDGGNGIKLIMEFLP
SGSLKEYLPKNKNKINLKQQLKYAVQICKGMDYLGSRQYVHRDLAARNVLVESEHQVKIG
DFGLTKAIETDKEYYTVKDDRDSPVFWYAPECLMQSKFYIASDVWSFGVTLHELLTYCDS
DSSPMALFLKMIGPTHGQMTVTRLVNTLKEGKRLPCPPNCPDEVYQLMRKCWEFQPSNRT
SFQNLIEGFEALLK
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  Blast E-value cutoff:
BDBM159781
n/a
NameBDBM159781
Synonyms:US10966980, Example 32 | US9035074, 32
TypeSmall organic molecule
Emp. Form.C17H24N4O2S
Mol. Mass.348.463
SMILESCN([C@@H]1C[C@H](CS(=O)(=O)CCC2CC2)C1)c1ncnc2[nH]ccc12 |r,wD:2.1,4.4,(-5.82,.84,;-4.49,.07,;-3.16,.84,;-3.16,2.38,;-1.62,2.38,;-.53,3.47,;.96,3.07,;1.36,4.55,;.56,1.58,;2.45,2.67,;2.85,1.18,;4.33,.78,;5.42,-.31,;5.82,1.18,;-1.62,.84,;-4.49,-1.47,;-5.82,-2.24,;-5.82,-3.78,;-4.49,-4.55,;-3.16,-3.78,;-1.69,-4.26,;-.79,-3.01,;-1.69,-1.77,;-3.16,-2.24,)|
Structure
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