| Reaction Details |
|---|
 | Report a problem with these data |
| Target | DNA topoisomerase 4 subunit A/B |
|---|
| Ligand | BDBM50393079 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ATPase Assay |
|---|
| Ki | 12±0.0 nM |
|---|
| Citation |  Shannon, D; Luisi, B; Krawiec, M; Kuldipkumar, AK Solid forms of gyrase inhibitor (R)-1-ethyl-3-[6-fluoro-5-[2-(1-hydroxy-1-methyl-ethyl)pryimidin-5-yl]-7-(tetrahydrofuran-2-yl)-1H-benzimidazol-2-yl]urea US Patent US9040542 Publication Date 5/26/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| DNA topoisomerase 4 subunit A/B |
|---|
| Name: | DNA topoisomerase 4 subunit A/B |
|---|
| Synonyms: | DNA topoisomerase 4 |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | n/a |
|---|
| Description: | n/a |
|---|
| Components: | This complex has 2 components. |
|---|
| Component 1 |
| Name: | DNA topoisomerase 4 subunit A |
|---|
| Synonyms: | DNA topoisomerase 4 subunit A (parC) | PARC_STAA8 | grlA | parC |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 90994.97 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | Q2FYS4 |
|---|
| Residue: | 800 |
|---|
| Sequence: | MSEIIQDLSLEDVLGDRFGRYSKYIIQERALPDVRDGLKPVQRRILYAMYSSGNTHDKNF
RKSAKTVGDVIGQYHPHGDSSVYEAMVRLSQDWKLRHVLIEMHGNNGSIDNDPPAAMRYT
EAKLSLLAEELLRDINKETVSFIPNYDDTTLEPMVLPSRFPNLLVNGSTGISAGYATDIP
PHNLAEVIQATLKYIDNPDITVNQLMKYIKGPDFPTGGIIQGIDGIKKAYESGKGRIIVR
SKVEEETLRNGRKQLIITEIPYEVNKSSLVKRIDELRADKKVDGIVEVRDETDRTGLRIA
IELKKDVNSESIKNYLYKNSDLQISYNFNMVAISDGRPKLMGIRQIIDSYLNHQIEVVAN
RTKFELDNAEKRMHIVEGLIKALSILDKVIELIRSSKNKRDAKENLIEVYEFTEEQAEAI
VMLQLYRLTNTDIVALEGEHKELEALIKQLRHILDNHDALLNVIKEELNEIKKKFKSERL
SLIEAEIEEIKIDKEVMVPSEEVILSMTRHGYIKRTSIRSFNASGVEDIGLKDGDSLLKH
QEVNTQDTVLVFTNKGRYLFIPVHKLADIRWKELGQHVSQIVPIEEDEVVINVFNEKDFN
TDAFYVFATQNGMIKKSTVPLFKTTRFNKPLIATKVKENDDLISVMRFEKDQLITVITNK
GMSLTYNTSELSDTGLRAAGVKSINLKAEDFVVMTEGVSENDTILMATQRGSLKRISFKI
LQVAKRAQRGITLLKELKKNPHRIVAAHVVTGEHSQYTLYSKSNEEHGLINDIHKSEQYT
NGSFIVDTDDFGEVIDMYIS
|
|
|
|---|
| Component 2 |
| Name: | DNA topoisomerase 4 subunit B |
|---|
| Synonyms: | DNA topoisomerase 4 subunit B | DNA topoisomerase 4 subunit B (parE) | PARE_STAA8 | Topoisomerase IV subunit B | grlB | parE |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 74365.92 |
|---|
| Organism: | Staphylococcus aureus |
|---|
| Description: | Q2FYS5 |
|---|
| Residue: | 663 |
|---|
| Sequence: | MNKQNNYSDDSIQVLEGLEAVRKRPGMYIGSTDKRGLHHLVYEIVDNSVDEVLNGYGNEI
DVTINKDGSISIEDNGRGMPTGIHKSGKPTVEVIFTVLHAGGKFGQGGYKTSGGLHGVGA
SVVNALSEWLEVEIHRDGNIYHQSFKNGGSPSSGLVKKGKTKKTGTKVTFKPDDTIFKAS
TSFNFDVLSERLQESAFLLKNLKITLNDLRSGKERQEHYHYEEGIKEFVSYVNEGKEVLH
DVATFSGEANGIEVDVAFQYNDQYSESILSFVNNVRTKDGGTHEVGFKTAMTRVFNDYAR
RINELKTKDKNLDGNDIREGLTAVVSVRIPEELLQFEGQTKSKLGTSEARSAVDSVVADK
LPFYLEEKGQLSKSLVKKAIKAQQAREAARKAREDARSGKKNKRKDTLLSGKLTPAQSKN
TEKNELYLVEGDSAGGSAKLGRDRKFQAILPLRGKVINTEKARLEDIFKNEEINTIIHTI
GAGVGTDFKIEDSNYNRVIIMTDADTDGAHIQVLLLTFFFKYMKPLVQAGRVFIALPPLY
KLEKGKGKTKRVEYAWTDEELNKLQKELGKGFTLQRYKGLGEMNPEQLWETTMNPETRTL
IRVQVEDEVRSSKRVTTLMGDKVQPRREWIEKHVEFGMQEDQSILDNSEVQVLENDQFDE
EEI
|
|
|
|---|
| BDBM50393079 |
|---|
| n/a |
|---|
| Name | BDBM50393079 |
|---|
| Synonyms: | CHEMBL2152855 | US9040542, 23 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C21H25FN6O3 |
|---|
| Mol. Mass. | 428.46 |
|---|
| SMILES | CCNC(=O)Nc1nc2cc(c(F)c([C@H]3CCCO3)c2[nH]1)-c1cnc(nc1)C(C)(C)O |r| |
|---|
| Structure | 
|
|---|
Search and Browse
