| Reaction Details |
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 | Report a problem with these data |
| Target | Epidermal growth factor receptor [668-1210,T790M,L858R] |
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| Ligand | BDBM50029668 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ssay of Inhibitory Activity on Wild Type EGFR and Mutant EGFR Kinase |
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| Temperature | 298.15±n/a K |
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| IC50 | 2.00±n/a nM |
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| Comments | extracted |
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| Citation |  Jin, Y; Bu, P; He, Q; Lan, J; Zhou, F; Zhang, L; He, X Azabicyclo derivatives, process for preparation thereof and medical use thereof US Patent US10085983 Publication Date 10/2/2018 |
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| More Info.: | Get all data from this article, Assay Method |
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| Epidermal growth factor receptor [668-1210,T790M,L858R] |
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| Name: | Epidermal growth factor receptor [668-1210,T790M,L858R] |
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| Synonyms: | EGFR | EGFR_HUMAN | ERBB | ERBB1 | Epidermal growth factor receptor (EGFR)(T790M/L858R) | HER1 |
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| Type: | Enzyme |
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| Mol. Mass.: | 61378.18 |
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| Organism: | Homo sapiens (Human) |
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| Description: | a.a: 668-1210 |
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| Residue: | 543 |
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| Sequence: | MRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGSGAFGTVY
KGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQ
LIMQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKT
PQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSYGVTVWEL
MTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPKFRELIIE
FSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQQGFFSSP
STSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTEDSIDDTFL
PVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLNTVQPTCV
NSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRVAPQSSEF
IGA
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| BDBM50029668 |
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| n/a |
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| Name | BDBM50029668 |
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| Synonyms: | AZD-9291 | Osimertinib | US10085983, Compound AZD-9291 | US10227342, Example 24 | US11111233, Example AZD9291 | US20230322822, Compound AZD9291 | US9890168, Compound AZD-9291 | WO2022090481, Example osimertinib |
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| Type | Small organic molecule |
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| Emp. Form. | C28H33N7O2 |
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| Mol. Mass. | 499.6073 |
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| SMILES | COc1cc(N(C)CCN(C)C)c(NC(=O)C=C)cc1Nc1nccc(n1)-c1cn(C)c2ccccc12 |
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| Structure | 
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