Reaction Details | |||
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Target | 5-hydroxytryptamine receptor 3A | ||
Ligand | BDBM50014552 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Radioligand Binding Assay | ||
pH | 7.5±n/a | ||
Temperature | 298.15±n/a K | ||
Ki | 0.5±n/a nM | ||
Comments | extracted | ||
Citation | Guzzo, PR; Manning, DD; Earley, W 5-HT3 receptor modulators, methods of making, and use thereof US Patent US9045501 Publication Date 6/2/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
5-hydroxytryptamine receptor 3A | |||
Name: | 5-hydroxytryptamine receptor 3A | ||
Synonyms: | 5-HT-3 | 5-HT3 | 5-HT3A | 5-HT3R | 5-hydroxytryptamine receptor 3 (5-HT3) | 5-hydroxytryptamine receptor 3A (5-HT3a) | 5-hydroxytryptamine receptor 3A (5HT3A) | 5HT3A_HUMAN | 5HT3R | HTR3 | HTR3A | Serotonin 3 (5-HT3) receptor | Serotonin 3 receptor (5HT3) | Serotonin receptor 3A | Serotonin-gated ion channel receptor | Serotonin-gated ion channel receptor 3 | ||
Type: | Protein | ||
Mol. Mass.: | 55283.27 | ||
Organism: | Homo sapiens (Human) | ||
Description: | P46098 | ||
Residue: | 478 | ||
Sequence: |
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BDBM50014552 | |||
n/a | |||
Name | BDBM50014552 | ||
Synonyms: | CHEMBL3261483 | US9045501, 8 | ||
Type | Small organic molecule | ||
Emp. Form. | C17H19ClN4O | ||
Mol. Mass. | 330.812 | ||
SMILES | Clc1cc2C(=O)N(CCn3ncc(c1)c23)[C@@H]1CN2CCC1CC2 |r,wD:15.17,(22.97,-13.82,;24.31,-13.05,;24.31,-11.51,;25.64,-10.74,;25.4,-9.21,;23.93,-8.77,;26.45,-8.07,;27.99,-8.19,;28.86,-9.46,;28.42,-10.93,;29.36,-12.28,;28.45,-13.53,;26.97,-13.05,;25.64,-13.82,;26.98,-11.51,;25.89,-6.64,;24.36,-6.41,;23.8,-4.97,;24.76,-3.77,;26.29,-4,;26.84,-5.43,;25.89,-4.4,;25.13,-5.74,)| | ||
Structure |