| Reaction Details |
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 | Report a problem with these data |
| Target | Bifunctional ligase/repressor BirA |
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| Ligand | BDBM161467 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Enzyme Inhibition Assay |
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| pH | 8±n/a |
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| Temperature | 310.15±n/a K |
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| Ki | >30000±n/a nM |
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| Comments | extracted |
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| Citation |  Abell, A; Polyak, S; Booker, G; Wallace, J; Soares da Costa, T; Jarrad, A; Tieu, W; Keeling, KL; Pedersen, DS; Pendini, N; Wilce, M; Yap, MY Antimicrobial compounds US Patent US9108978 Publication Date 8/18/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Bifunctional ligase/repressor BirA |
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| Name: | Bifunctional ligase/repressor BirA |
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| Synonyms: | BIRA_ECOLI | Biotin operon repressor | Biotin protein ligase (BPL) | Biotin--[acetyl-CoA-carboxylase] synthetase | BirA Bifunctional Protein | bioR | birA | dhbB |
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| Type: | Repressor protein |
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| Mol. Mass.: | 35313.58 |
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| Organism: | Escherichia coli |
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| Description: | n/a |
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| Residue: | 321 |
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| Sequence: | MKDNTVPLKLIALLANGEFHSGEQLGETLGMSRAAINKHIQTLRDWGVDVFTVPGKGYSL
PEPIQLLNAKQILGQLDGGSVAVLPVIDSTNQYLLDRIGELKSGDACIAEYQQAGRGRRG
RKWFSPFGANLYLSMFWRLEQGPAAAIGLSLVIGIVMAEVLRKLGADKVRVKWPNDLYLQ
DRKLAGILVELTGKTGDAAQIVIGAGINMAMRRVEESVVNQGWITLQEAGINLDRNTLAA
MLIRELRAALELFEQEGLAPYLSRWEKLDNFINRPVKLIIGDKEIFGISRGIDKQGALLL
EQDGIIKPWMGGEISLRSAEK
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| BDBM161467 |
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| n/a |
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| Name | BDBM161467 |
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| Synonyms: | US9108978, 3.25 |
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| Type | Small organic molecule |
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| Emp. Form. | C25H34N10O4S |
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| Mol. Mass. | 570.667 |
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| SMILES | CC1(C)O[C@H]2[C@H](Cn3cc(CCCCC[C@@H]4SC[C@@H]5NC(=O)N[C@H]45)nn3)O[C@@H]([C@H]2O1)n1cnc2c(N)ncnc12 |r| |
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| Structure | 
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