| Reaction Details |
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 | Report a problem with these data |
| Target | Apoptosis regulator Bcl-2 |
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| Ligand | BDBM161600 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence Polarisation Assay |
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| pH | 7.4±n/a |
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| IC50 | 3±n/a nM |
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| Comments | extracted |
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| Citation |  Le Tiran, A; Le Diguarher, T; Starck, J; Henlin, J; Guillouzic, A; De Nanteuil, G; Geneste, O; Fejes, I; Tatai, J; Nyerges, M; Davidson, JE; Murray, JB; Chen, I; Durand, D Pyrrole compounds, a process for their preparation and pharmaceutical compositions containing them US Patent US9108983 Publication Date 8/18/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Apoptosis regulator Bcl-2 |
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| Name: | Apoptosis regulator Bcl-2 |
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| Synonyms: | Apoptosis regulator Bcl-2 Protein | B-cell lymphoma 2 protein (Bcl-2) | BCL-2 | BCL2 | BCL2_HUMAN | Bcl-2 Protein |
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| Type: | Homodimer or heterodimer |
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| Mol. Mass.: | 26269.11 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P10415 |
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| Residue: | 239 |
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| Sequence: | MAHAGRTGYDNREIVMKYIHYKLSQRGYEWDAGDVGAAPPGAAPAPGIFSSQPGHTPHPA
ASRDPVARTSPLQTPAAPGAAAGPALSPVPPVVHLTLRQAGDDFSRRYRRDFAEMSSQLH
LTPFTARGRFATVVEELFRDGVNWGRIVAFFEFGGVMCVESVNREMSPLVDNIALWMTEY
LNRHLHTWIQDNGGWDAFVELYGPSMRPLFDFSWLSLKTLLSLALVGACITLGAYLGHK
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| BDBM161600 |
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| n/a |
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| Name | BDBM161600 |
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| Synonyms: | US9108983, Example 417 |
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| Type | Small organic molecule |
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| Emp. Form. | C42H44N6O5 |
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| Mol. Mass. | 712.836 |
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| SMILES | COc1ccc(-c2cc(C(=O)N(c3cc(C#N)n(C)c3C)c3ccc(O)cc3)c(C)n2C)c(c1)C(=O)N1Cc2ccccc2C[C@H]1CN1CCOCC1 |
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| Structure | 
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