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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | E3 ubiquitin-protein ligase Mdm2 | ||
| Ligand | BDBM162147 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay | ||
| IC50 | 1.7±n/a nM | ||
| Citation |  Berghausen, J; Buschmann, N; Furet, P; Gessier, F; Hergovich Lisztwan, J; Holzer, P; Jacoby, E; Kallen, J; Masuya, K; Pissot Soldermann, C; Ren, H; Stutz, S Substituted isoquinolinones and quinazolinones US Patent US9051279 Publication Date 6/9/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| E3 ubiquitin-protein ligase Mdm2 | |||
| Name: | E3 ubiquitin-protein ligase Mdm2 | ||
| Synonyms: | Double minute 2 protein | Double minute 2 protein (HDM2) | E3 ubiquitin-protein ligase Mdm2 (p53-binding protein Mdm2) | Hdm2 | Human Double Minute 2 (HDM2) | MDM2 | MDM2-MDMX | MDM2_HUMAN | p53-Binding Protein MDM2 | p53-binding protein | ||
| Type: | Oncoprotein | ||
| Mol. Mass.: | 55196.54 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q00987 | ||
| Residue: | 491 | ||
| Sequence: |
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| BDBM162147 | |||
| n/a | |||
| Name | BDBM162147 | ||
| Synonyms: | US9051279, 130 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C37H46ClN5O4 | ||
| Mol. Mass. | 660.245 | ||
| SMILES | COc1cc2CC(=O)N([C@@H](c3ccc(Cl)cc3)c2cc1OC(C)C)c1ccc(nc1)N(C)C[C@H]1CC[C@@H](CC1)N1CCN(C)C(=O)C1 |r,wU:36.43,wD:9.9,33.36,(12,5,;10.67,5.78,;9.34,5,;8,5.78,;6.67,5,;5.33,5.78,;4,5,;2.67,5.78,;4,3.47,;5.33,2.69,;5.33,1.15,;4,.38,;4,-1.15,;5.33,-1.93,;5.33,-3.47,;6.67,-1.15,;6.67,.38,;6.67,3.47,;8,2.69,;9.34,3.47,;10.67,2.69,;10.67,1.15,;12,.38,;9.34,.38,;2.67,2.69,;2.67,1.15,;1.33,.38,;,1.15,;,2.69,;1.33,3.47,;-1.33,.38,;-1.33,-1.15,;-2.67,1.15,;-4,.38,;-5.33,1.15,;-6.67,.38,;-6.67,-1.15,;-5.33,-1.93,;-4,-1.15,;-8,-1.93,;-9.34,-1.15,;-10.67,-1.93,;-10.67,-3.47,;-12,-4.23,;-9.34,-4.23,;-9.34,-5.78,;-8,-3.47,)| | ||
| Structure | 
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