Reaction Details | |||
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Target | Protein Mdm4 | ||
Ligand | BDBM162151 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Time Resolved Fluorescence Energy Transfer (TR-FRET) Assay | ||
IC50 | 5090±n/a nM | ||
Citation | Berghausen, J; Buschmann, N; Furet, P; Gessier, F; Hergovich Lisztwan, J; Holzer, P; Jacoby, E; Kallen, J; Masuya, K; Pissot Soldermann, C; Ren, H; Stutz, S Substituted isoquinolinones and quinazolinones US Patent US9051279 Publication Date 6/9/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Protein Mdm4 | |||
Name: | Protein Mdm4 | ||
Synonyms: | Double minute 4 protein | Double minute 4 protein (HDM4) | MDM2-MDMX | MDM4 | MDM4_HUMAN | MDMX | Mdm2-like p53-binding protein | Protein Mdm4 | Protein Mdmx | p53-Binding Protein HDMX | p53-binding protein | p53-binding protein Mdm4 | ||
Type: | Oncoprotein | ||
Mol. Mass.: | 54842.04 | ||
Organism: | Homo sapiens (Human) | ||
Description: | The HDMX(1-188) were expressed in Escherichia coli BL21 (DE3) as a GST fusion and purified on glutathione sepharose. | ||
Residue: | 490 | ||
Sequence: |
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BDBM162151 | |||
n/a | |||
Name | BDBM162151 | ||
Synonyms: | US9051279, 134 | ||
Type | Small organic molecule | ||
Emp. Form. | C37H46ClN5O4 | ||
Mol. Mass. | 660.245 | ||
SMILES | CCN1CN(CC1=O)[C@H]1CC[C@H](CN(C)c2ccc(cn2)N2[C@@H](c3ccc(Cl)cc3)c3cc(OC(C)C)c(OC)cc3CC2=O)CC1 |r,wU:8.8,wD:22.24,11.12,(-9.51,-6.19,;-10.28,-4.86,;-9.51,-3.52,;-8.05,-3.05,;-8.05,-1.51,;-9.51,-1.03,;-10.42,-2.28,;-11.96,-2.28,;-6.71,-.74,;-6.71,.8,;-5.38,1.57,;-4.05,.8,;-2.71,1.57,;-1.38,.8,;-1.38,-.74,;-.05,1.57,;1.29,.8,;2.62,1.57,;2.62,3.11,;1.29,3.88,;-.05,3.11,;3.96,3.88,;5.29,3.11,;5.29,1.57,;3.96,.8,;3.96,-.74,;5.29,-1.51,;5.29,-3.05,;6.62,-.74,;6.62,.8,;6.62,3.88,;7.96,3.11,;9.29,3.88,;10.62,3.11,;10.62,1.57,;11.96,.8,;9.29,.8,;9.29,5.42,;10.62,6.19,;11.96,5.42,;7.96,6.19,;6.62,5.42,;5.29,6.19,;3.96,5.42,;2.62,6.19,;-4.05,-.74,;-5.38,-1.51,)| | ||
Structure |