Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetSmoothened homolog
LigandBDBM162971
Substrate/Competitorn/a
Meas. Tech.Radioligand Competition Binding Assay
Temperature298.15±n/a K
IC50 12.4±n/a nM
Commentsextracted
Citation Nair, SKPlanken, SP Pyridine-2-derivatives as smoothened receptor modulators US Patent US9056865 Publication Date 6/16/2015
More Info.:Get all data from this article,  Assay Method
 
Smoothened homolog
Name:Smoothened homolog
Synonyms:G-protein- coupled-like receptor Smoothened (Smo) | SMO | SMOH | SMO_HUMAN | Smoothened homolog
Type:Protein
Mol. Mass.:86415.51
Organism:Homo sapiens (Human)
Description:Q99835
Residue:787
Sequence:
MAAARPARGPELPLLGLLLLLLLGDPGRGAASSGNATGPGPRSAGGSARRSAAVTGPPPP
LSHCGRAAPCEPLRYNVCLGSVLPYGATSTLLAGDSDSQEEAHGKLVLWSGLRNAPRCWA
VIQPLLCAVYMPKCENDRVELPSRTLCQATRGPCAIVERERGWPDFLRCTPDRFPEGCTN
EVQNIKFNSSGQCEVPLVRTDNPKSWYEDVEGCGIQCQNPLFTEAEHQDMHSYIAAFGAV
TGLCTLFTLATFVADWRNSNRYPAVILFYVNACFFVGSIGWLAQFMDGARREIVCRADGT
MRLGEPTSNETLSCVIIFVIVYYALMAGVVWFVVLTYAWHTSFKALGTTYQPLSGKTSYF
HLLTWSLPFVLTVAILAVAQVDGDSVSGICFVGYKNYRYRAGFVLAPIGLVLIVGGYFLI
RGVMTLFSIKSNHPGLLSEKAASKINETMLRLGIFGFLAFGFVLITFSCHFYDFFNQAEW
ERSFRDYVLCQANVTIGLPTKQPIPDCEIKNRPSLLVEKINLFAMFGTGIAMSTWVWTKA
TLLIWRRTWCRLTGQSDDEPKRIKKSKMIAKAFSKRHELLQNPGQELSFSMHTVSHDGPV
AGLAFDLNEPSADVSSAWAQHVTKMVARRGAILPQDISVTPVATPVPPEEQANLWLVEAE
ISPELQKRLGRKKKRRKRKKEVCPLAPPPELHPPAPAPSTIPRLPQLPRQKCLVAAGAWG
AGDSCRQGAWTLVSNPFCPEPSPPQDPFLPSAPAPVAWAHGRRQGLGPIHSRTNLMDTEL
MDADSDF
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM162971
n/a
NameBDBM162971
Synonyms:US9056865, A-98
TypeSmall organic molecule
Emp. Form.C19H24ClN3O2S
Mol. Mass.393.931
SMILESCc1cnc(c(C)c1)-c1cc(ncc1Cl)N1CCC(CS(C)(=O)=O)CC1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: