| Reaction Details |
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 | Report a problem with these data |
| Target | Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498] |
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| Ligand | BDBM163623 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | HDAC Activity Assays |
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| IC50 | 4.3e+2±n/a nM |
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| Citation |  Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498] |
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| Name: | Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498] |
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| Synonyms: | HDAC3/NCOR2 |
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| Type: | Protein |
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| Mol. Mass.: | n/a |
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| Description: | BPS Bioscience |
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| Components: | This complex has 2 components. |
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| Component 1 |
| Name: | Histone deacetylase 3 |
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| Synonyms: | HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45 |
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| Type: | Enzyme |
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| Mol. Mass.: | 48829.55 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15379 |
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| Residue: | 428 |
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| Sequence: | MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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| Component 2 |
| Name: | Nuclear receptor corepressor 2 [395-498] |
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| Synonyms: | CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 |
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| Type: | Protein |
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| Mol. Mass.: | 12719.17 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Deacetylase activation domain of human NCOR2 (395-498aa) |
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| Residue: | 104 |
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| Sequence: | IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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| BDBM163623 |
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| n/a |
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| Name | BDBM163623 |
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| Synonyms: | SR-3206 | US10807944, Compound RLS2-126 | US10870618, Compound 1a | US11731934, Compound RLS2-126 |
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| Type | Small organic molecule |
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| Emp. Form. | C12H18N2O2 |
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| Mol. Mass. | 222.2835 |
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| SMILES | CCCCNNC(=O)c1ccc(OC)cc1 |
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| Structure | 
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