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TargetHistone deacetylase 1/Nuclear receptor corepressor 2 [395-498]
LigandBDBM163624
Substrate/Competitorn/a
Meas. Tech.HDAC Activity Assays
IC50 2.3e+2±n/a nM
Citation Wang, YStowe, RLPinello, CETian, GMadoux, FLi, DZhao, LYLi, JLWang, YWang, YMa, HHodder, PRoush, WRLiao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498]
Name:Histone deacetylase 1/Nuclear receptor corepressor 2 [395-498]
Synonyms:HDAC1/NCOR2
Type:Protein
Mol. Mass.:n/a
Description:BPS Bioscience
Components:This complex has 2 components.
Component 1
Name:Histone deacetylase 1
Synonyms:Cereblon/Histone deacetylase 1 | HD1 | HDAC1 | HDAC1_HUMAN | Histone deacetylase 1 (HDAC1) | Human HDAC1 | RPD3L1
Type:Enzyme
Mol. Mass.:55090.27
Organism:Homo sapiens (Human)
Description:Q13547
Residue:482
Sequence:
MAQTQGTRRKVCYYYDGDVGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKAN
AEEMTKYHSDDYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVAS
AVKLNKQQTDIAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHHG
DGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNYPLRDGIDDESYEAI
FKPVMSKVMEMFQPSAVVLQCGSDSLSGDRLGCFNLTIKGHAKCVEFVKSFNLPMLMLGG
GGYTIRNVARCWTYETAVALDTEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTNEYLE
KIKQRLFENLRMLPHAPGVQMQAIPEDAIPEESGDEDEDDPDKRISICSSDKRIACEEEF
SDSEEEGEGGRKNSSNFKKAKRVKTEDEKEKDPEEKKEVTEEEKTKEEKPEAKGVKEEVK
LA
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Component 2
Name:Nuclear receptor corepressor 2 [395-498]
Synonyms:CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2
Type:Protein
Mol. Mass.:12719.17
Organism:Homo sapiens (Human)
Description:Deacetylase activation domain of human NCOR2 (395-498aa)
Residue:104
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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BDBM163624
n/a
NameBDBM163624
Synonyms:SR-3208 | US10807944, Compound RLS2-131 | US11731934, Compound RLS2-131
TypeSmall organic molecule
Emp. Form.C13H21N3O
Mol. Mass.235.3253
SMILESCCCCNNC(=O)c1ccc(cc1)N(C)C
Structure
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