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TargetHistone deacetylase 2/Nuclear receptor corepressor 2 [395-498]
LigandBDBM163629
Substrate/Competitorn/a
Meas. Tech.HDAC Activity Assays
IC50 1.92e+3±n/a nM
Citation Wang, YStowe, RLPinello, CETian, GMadoux, FLi, DZhao, LYLi, JLWang, YWang, YMa, HHodder, PRoush, WRLiao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498]
Name:Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498]
Synonyms:HDAC2/NCOR2
Type:Protein
Mol. Mass.:n/a
Description:BPS Bioscience
Components:This complex has 2 components.
Component 1
Name:Histone deacetylase 2
Synonyms:Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2
Type:Chromatin regulator; hydrolase; repressor
Mol. Mass.:55356.54
Organism:Homo sapiens (Human)
Description:Q92769
Residue:488
Sequence:
MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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Component 2
Name:Nuclear receptor corepressor 2 [395-498]
Synonyms:CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2
Type:Protein
Mol. Mass.:12719.17
Organism:Homo sapiens (Human)
Description:Deacetylase activation domain of human NCOR2 (395-498aa)
Residue:104
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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BDBM163629
n/a
NameBDBM163629
Synonyms:SR-3970
TypeSmall organic molecule
Emp. Form.C12H17BrN2O
Mol. Mass.285.18
SMILESCCCCCNNC(=O)c1ccc(Br)cc1
Structure
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