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TargetHistone deacetylase 3/Nuclear receptor corepressor 2 [395-498]
LigandBDBM163629
Substrate/Competitorn/a
Meas. Tech.HDAC Activity Assays
IC50 9.2e+2±n/a nM
Citation Wang, YStowe, RLPinello, CETian, GMadoux, FLi, DZhao, LYLi, JLWang, YWang, YMa, HHodder, PRoush, WRLiao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed]  Article
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Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498]
Name:Histone deacetylase 3/Nuclear receptor corepressor 2 [395-498]
Synonyms:HDAC3/NCOR2
Type:Protein
Mol. Mass.:n/a
Description:BPS Bioscience
Components:This complex has 2 components.
Component 1
Name:Histone deacetylase 3
Synonyms:HD3 | HDAC3 | HDAC3_HUMAN | Histone deacetylase 3 (HDAC3) | Human HDAC3 | RPD3-2 | SMAP45
Type:Enzyme
Mol. Mass.:48829.55
Organism:Homo sapiens (Human)
Description:O15379
Residue:428
Sequence:
MAKTVAYFYDPDVGNFHYGAGHPMKPHRLALTHSLVLHYGLYKKMIVFKPYQASQHDMCR
FHSEDYIDFLQRVSPTNMQGFTKSLNAFNVGDDCPVFPGLFEFCSRYTGASLQGATQLNN
KICDIAINWAGGLHHAKKFEASGFCYVNDIVIGILELLKYHPRVLYIDIDIHHGDGVQEA
FYLTDRVMTVSFHKYGNYFFPGTGDMYEVGAESGRYYCLNVPLRDGIDDQSYKHLFQPVI
NQVVDFYQPTCIVLQCGADSLGCDRLGCFNLSIRGHGECVEYVKSFNIPLLVLGGGGYTV
RNVARCWTYETSLLVEEAISEELPYSEYFEYFAPDFTLHPDVSTRIENQNSRQYLDQIRQ
TIFENLKMLNHAPSVQIHDVPADLLTYDRTDEADAEERGPEENYSRPEAPNEFYDGDHDN
DKESDVEI
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Component 2
Name:Nuclear receptor corepressor 2 [395-498]
Synonyms:CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2
Type:Protein
Mol. Mass.:12719.17
Organism:Homo sapiens (Human)
Description:Deacetylase activation domain of human NCOR2 (395-498aa)
Residue:104
Sequence:
IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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BDBM163629
n/a
NameBDBM163629
Synonyms:SR-3970
TypeSmall organic molecule
Emp. Form.C12H17BrN2O
Mol. Mass.285.18
SMILESCCCCCNNC(=O)c1ccc(Br)cc1
Structure
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