Reaction Details |
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Target | Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498] |
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Ligand | BDBM163634 |
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Substrate/Competitor | n/a |
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Meas. Tech. | HDAC Activity Assays |
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IC50 | >5.0e+4±n/a nM |
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Citation | Wang, Y; Stowe, RL; Pinello, CE; Tian, G; Madoux, F; Li, D; Zhao, LY; Li, JL; Wang, Y; Wang, Y; Ma, H; Hodder, P; Roush, WR; Liao, D Identification of histone deacetylase inhibitors with benzoylhydrazide scaffold that selectively inhibit class I histone deacetylases. Chem Biol22:273-84 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498] |
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Name: | Histone deacetylase 2/Nuclear receptor corepressor 2 [395-498] |
Synonyms: | HDAC2/NCOR2 |
Type: | Protein |
Mol. Mass.: | n/a |
Description: | BPS Bioscience |
Components: | This complex has 2 components. |
Component 1 |
Name: | Histone deacetylase 2 |
Synonyms: | Cereblon/Histone deacetylase 2 | HD2 | HDAC2 | HDAC2_HUMAN | Histone deacetylase 2 (HDAC2) | Human HDAC2 |
Type: | Chromatin regulator; hydrolase; repressor |
Mol. Mass.: | 55356.54 |
Organism: | Homo sapiens (Human) |
Description: | Q92769 |
Residue: | 488 |
Sequence: | MAYSQGGGKKKVCYYYDGDIGNYYYGQGHPMKPHRIRMTHNLLLNYGLYRKMEIYRPHKA
TAEEMTKYHSDEYIKFLRSIRPDNMSEYSKQMQRFNVGEDCPVFDGLFEFCQLSTGGSVA
GAVKLNRQQTDMAVNWAGGLHHAKKSEASGFCYVNDIVLAILELLKYHQRVLYIDIDIHH
GDGVEEAFYTTDRVMTVSFHKYGEYFPGTGDLRDIGAGKGKYYAVNFPMRDGIDDESYGQ
IFKPIISKVMEMYQPSAVVLQCGADSLSGDRLGCFNLTVKGHAKCVEVVKTFNLPLLMLG
GGGYTIRNVARCWTYETAVALDCEIPNELPYNDYFEYFGPDFKLHISPSNMTNQNTPEYM
EKIKQRLFENLRMLPHAPGVQMQAIPEDAVHEDSGDEDGEDPDKRISIRASDKRIACDEE
FSDSEDEGEGGRRNVADHKKGAKKARIEEDKKETEDKKTDVKEEDKSKDNSGEKTDTKGT
KSEQLSNP
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Component 2 |
Name: | Nuclear receptor corepressor 2 [395-498] |
Synonyms: | CTG26 | Deacetylase activation domain (NCOR2) | NCOR2 | NCOR2_HUMAN | Nuclear receptor corepressor 2 |
Type: | Protein |
Mol. Mass.: | 12719.17 |
Organism: | Homo sapiens (Human) |
Description: | Deacetylase activation domain of human NCOR2 (395-498aa) |
Residue: | 104 |
Sequence: | IPPMLYDADQQRIKFINMNGLMADPMKVYKDRQVMNMWSEQEKETFREKFMQHPKNFGLI
ASFLERKTVAECVLYYYLTKKNENYKSLVRRSYRRRGKSQQQQQ
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BDBM163634 |
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n/a |
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Name | BDBM163634 |
Synonyms: | SR-3365 | US10807944, Compound RLS2-257 | US11731934, Compound RLS2-257 |
Type | Small organic molecule |
Emp. Form. | C15H21BrN2O |
Mol. Mass. | 325.244 |
SMILES | Brc1ccc(cc1)C(=O)NNCCCC1CCCC1 |
Structure |
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