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TargetBeta-glucuronidase (EcGUS)
LigandBDBM163644
Substrate/Competitorn/a
Meas. Tech.Inhibition Assays
Ki 1.9e+3± 5e+2 nM
Citation Wallace BDRoberts ABPollet RMIngle JDBiernat KAPellock SJVenkatesh MKGuthrie LO'Neal SKRobinson SJDollinger MFigueroa EMcShane SRCohen RDJin JFrye SVZamboni WCPepe-Ranney CMani SKelly LRedinbo MR Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol 22:1238-49 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-glucuronidase (EcGUS)
Name:Beta-glucuronidase (EcGUS)
Synonyms:β-Glucuronidase
Type:Protein
Mol. Mass.:68431.57
Organism:Escherichia coli (Enterobacteria)
Description:P05804
Residue:603
Sequence:
MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI
RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP
YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP
NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH
LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD
LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS
LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG
AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET
AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV
SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG
GKQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM163644
n/a
NameBDBM163644
Synonyms:3[(6,8Dimethyl2oxo1Hquinolin3yl)methyl]3(2hydroxyethyl)1(4hydroxyphenyl)thiourea (Inhibitor R1)
TypeSmall organic molecule
Emp. Form.C21H23N3O3S
Mol. Mass.397.491
SMILESCc1cc(C)c2[nH]c(=O)c(CN(CCO)C(=S)Nc3ccc(O)cc3)cc2c1
Structure
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