Ki Summary new BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetBeta-glucuronidase (EcGUS)
LigandBDBM163640
Substrate/Competitorn/a
Meas. Tech.Inhibition Assays
Ki 2.2e+2± 4e+1 nM
Citation Wallace BDRoberts ABPollet RMIngle JDBiernat KAPellock SJVenkatesh MKGuthrie LO'Neal SKRobinson SJDollinger MFigueroa EMcShane SRCohen RDJin JFrye SVZamboni WCPepe-Ranney CMani SKelly LRedinbo MR Structure and Inhibition of Microbiome -Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol 22:1238-49 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Beta-glucuronidase (EcGUS)
Name:Beta-glucuronidase (EcGUS)
Synonyms:β-Glucuronidase
Type:Protein
Mol. Mass.:68431.57
Organism:Escherichia coli (Enterobacteria)
Description:P05804
Residue:603
Sequence:
MLRPVETPTREIKKLDGLWAFSLDRENCGIDQRWWESALQESRAIAVPGSFNDQFADADI
RNYAGNVWYQREVFIPKGWAGQRIVLRFDAVTHYGKVWVNNQEVMEHQGGYTPFEADVTP
YVIAGKSVRITVCVNNELNWQTIPPGMVITDENGKKKQSYFHDFFNYAGIHRSVMLYTTP
NTWVDDITVVTHVAQDCNHASVDWQVVANGDVSVELRDADQQVVATGQGTSGTLQVVNPH
LWQPGEGYLYELCVTAKSQTECDIYPLRVGIRSVAVKGEQFLINHKPFYFTGFGRHEDAD
LRGKGFDNVLMVHDHALMDWIGANSYRTSHYPYAEEMLDWADEHGIVVIDETAAVGFNLS
LGIGFEAGNKPKELYSEEAVNGETQQAHLQAIKELIARDKNHPSVVMWSIANEPDTRPQG
AREYFAPLAEATRKLDPTRPITCVNVMFCDAHTDTISDLFDVLCLNRYYGWYVQSGDLET
AEKVLEKELLAWQEKLHQPIIITEYGVDTLAGLHSMYTDMWSEEYQCAWLDMYHRVFDRV
SAVVGEQVWNFADFATSQGILRVGGNKKGIFTRDRKPKSAAFLLQKRWTGMNFGEKPQQG
GKQ
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM163640
n/a
NameBDBM163640
Synonyms:5,11Dimethyl3(piperazin1yl)8thia4,6diazatricyclo[7.4.0.0,⁷]trideca1(9),2(7),3,5tetraene (Inh 5) | US9334288, 5
TypeSmall organic molecule
Emp. Form.C16H22N4S
Mol. Mass.302.438
SMILESCC1CCc2c(C1)sc1nc(C)nc(N3CCNCC3)c21
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: