| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-glucuronidase (CpGUS) |
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| Ligand | BDBM163641 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assays |
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| Ki | 6.1e+3± 2e+3 nM |
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| Citation |  Wallace BD; Roberts AB; Pollet RM; Ingle JD; Biernat KA; Pellock SJ; Venkatesh MK; Guthrie L; O'Neal SK; Robinson SJ; Dollinger M; Figueroa E; McShane SR; Cohen RD; Jin J; Frye SV; Zamboni WC; Pepe-Ranney C; Mani S; Kelly L; Redinbo MR Structure and Inhibition of Microbiome ß-Glucuronidases Essential to the Alleviation of Cancer Drug Toxicity. Chem Biol 22:1238-49 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-glucuronidase (CpGUS) |
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| Name: | Beta-glucuronidase (CpGUS) |
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| Synonyms: | n/a |
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| Type: | Protein |
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| Mol. Mass.: | 68709.58 |
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| Organism: | Clostridium perfringens (Firmicutes) |
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| Description: | A0A0N9KAE4 |
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| Residue: | 599 |
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| Sequence: | MLYPIITESRQLIDLSGIWKFKLNEGNGLTEELSKAPLEDTIEMAVPSSYNDLVESQEVR
DHVGWVWYERNFTIPKTLLNERIVLRFGSATHEAKVYLNGELLVEHKGGFTPFEAEINDL
LVSGDNRLTVAVNNIIDETTLPVGLVKEVEIDGKKVIKNSVNFDFFNYAGIHRPVKIYTT
PKSYVEDITIVTDFKENNGYVNYEVQAVGKCNIKVTIIDEENNIVAEGEGKEGKLTINNV
HLWEPMNAYLYKLKVELLDDEEIIDTYFEEFGVRTVEVKDGKFLINNKPFYFKGFGKHED
SYVNGRGINEAINIKDFNLMKWIGANSFRTSHYPYSEEIMRLADREGIVVIDETPAVGLH
LNFMATGFGGDAPKRDTWKEIGTKEAHERILRELVSRDKNHPCVVMWSVANEPDSDSEGA
KEYFEPLIKLTKELDPQKRPVTVVTYLMSTPDRCKVGDIVDVLCLNRYYGWYVAGGDLEE
AKRMLEDELKGWEERCPKTPIMFTEYGADTVAGLHDTVPVMFTEEYQVEYYKANHEVMDK
CKNFVGEQVWNFADFATSQGIIRVQGNKKGIFTRERKPKMIAHSLRERWTNIPEFGYKK
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| BDBM163641 |
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| n/a |
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| Name | BDBM163641 |
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| Synonyms: | 1[2(3Fluorophenyl)5H,6H,7H,8Hpyrazolo[3,2b]quinazolin9yl]piperazine (Inh 6) | US9334288, 7 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H22FN5 |
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| Mol. Mass. | 351.4206 |
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| SMILES | Fc1cccc(c1)-c1cc2nc3CCCCc3c(N3CCNCC3)n2n1 |
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| Structure | 
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