| Reaction Details |
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 | Report a problem with these data |
| Target | Rhomboid-related protein 1 |
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| Ligand | BDBM50199883 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Activity-based Protein Profiling (ABPP) |
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| pH | 7.4±0 |
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| Temperature | 310.15±0 K |
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| IC50 | 2.8e+4± 9e+3 nM |
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| Citation |  Wolf, EV; Zeissler, A; Verhelst, SH Inhibitor Fingerprinting of Rhomboid Proteases by Activity-Based Protein Profiling Reveals Inhibitor Selectivity and Rhomboid Autoprocessing. ACS Chem Biol10:2325-33 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| Rhomboid-related protein 1 |
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| Name: | Rhomboid-related protein 1 |
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| Synonyms: | RHBL1_MOUSE | Rhbdl | Rhbdl1 | Rhomboid protease (MmRHBDL1) | Rhomboid-related protein 1 |
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| Type: | Protein |
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| Mol. Mass.: | 41795.66 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | n/a |
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| Residue: | 373 |
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| Sequence: | MDRSSLLQLIQEQQLDPENTGFIGADTFAGLVHSHELPLDPTKLDMLVALAQSNERGQVC
YQELVDLISSKRSSSFKRAIANGQRALPRDGLLDEPGLSVYKRFVRYVAYEILPCEVDRR
WYFYRHRTCPPPVFMASVTLAQIIVFLCYGARLNKWVLQTYHPEYMKSPLVYHPGHRARA
WRFLTYMFMHVGLEQLGFNALLQLMIGVPLEMVHGVLRISLLYLAGVLAGSLTVSITDMR
APVVGGSGGVYALCSAHLANVVMNWAGMRCPYKLLRMVLALVCMSSEVGRAVWLRFSPPL
PASGPQPSFMAHLAGAVVGVSMGLTILRSYEERLRDQCGWWVVLLAYGTFLLFAIFWNVF
AYDLLGADIPPPP
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| BDBM50199883 |
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| n/a |
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| Name | BDBM50199883 |
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| Synonyms: | 3,4‐Dichloroisocoumarin (2) | 3,4-Dichloro-isochromen-1-one | 3,4-dichloro-1H-isochromen-1-one | 3,4-dichloroisocoumarin | CHEMBL24983 | cid_1609 |
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| Type | Small organic molecule |
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| Emp. Form. | C9H4Cl2O2 |
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| Mol. Mass. | 215.033 |
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| SMILES | Clc1oc(=O)c2ccccc2c1Cl |
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| Structure | 
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