| Reaction Details |
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 | Report a problem with these data |
| Target | N-glycosylase/DNA lyase |
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| Ligand | BDBM163682 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Gel-based Cleavage Assay |
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| IC50 | 6.3e+2± 1.8e+2 nM |
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| Citation |  Donley, N; Jaruga, P; Coskun, E; Dizdaroglu, M; McCullough, AK; Lloyd, RS Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol10:2334-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-glycosylase/DNA lyase |
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| Name: | N-glycosylase/DNA lyase |
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| Synonyms: | 8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1 |
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| Type: | Protein |
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| Mol. Mass.: | 38794.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15527 |
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| Residue: | 345 |
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| Sequence: | MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA
DQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHF
QEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHG
FPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKAL
CILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELG
NFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
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| BDBM163682 |
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| n/a |
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| Name | BDBM163682 |
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| Synonyms: | 4‐Bromo‐N'‐cyclohexylidenebenzohydrazide (0151) |
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| Type | Small organic molecule |
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| Emp. Form. | C13H15BrN2O |
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| Mol. Mass. | 295.175 |
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| SMILES | Brc1ccc(cc1)-[#6](=O)-[#7]\[#7]=[#6]-1/[#6]-[#6]-[#6]-[#6]-[#6]-1 |
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| Structure | 
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