Reaction Details |
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Target | N-glycosylase/DNA lyase |
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Ligand | BDBM163681 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Fluorescence-based Assay |
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pH | 7.5±n/a |
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Temperature | 310.15±n/a K |
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IC50 | 4.2e+2± 9e+1 nM |
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Comments | extracted |
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Citation | Donley, N; Jaruga, P; Coskun, E; Dizdaroglu, M; McCullough, AK; Lloyd, RS Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol10:2334-43 (2015) [PubMed] Article |
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More Info.: | Get all data from this article, Assay Method |
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N-glycosylase/DNA lyase |
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Name: | N-glycosylase/DNA lyase |
Synonyms: | 8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1 |
Type: | Protein |
Mol. Mass.: | 38794.33 |
Organism: | Homo sapiens (Human) |
Description: | O15527 |
Residue: | 345 |
Sequence: | MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA
DQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHF
QEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHG
FPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKAL
CILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELG
NFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
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BDBM163681 |
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n/a |
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Name | BDBM163681 |
Synonyms: | 3-Chloro‐N'‐[(1E)‐(4‐fluorophenyl)methylidene]‐1‐ benzothiophene‐2‐carbohydrazide (0167) |
Type | Small organic molecule |
Emp. Form. | C16H10ClFN2OS |
Mol. Mass. | 332.78 |
SMILES | Fc1ccc(\C=N\NC(=O)c2sc3ccccc3c2Cl)cc1 |
Structure |
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