| Reaction Details |
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 | Report a problem with these data |
| Target | N-glycosylase/DNA lyase |
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| Ligand | BDBM163681 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Fluorescence-based Assay |
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| pH | 7.5±n/a |
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| Temperature | 310.15±n/a K |
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| IC50 | 4.2e+2± 9e+1 nM |
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| Comments | extracted |
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| Citation |  Donley, N; Jaruga, P; Coskun, E; Dizdaroglu, M; McCullough, AK; Lloyd, RS Small Molecule Inhibitors of 8-Oxoguanine DNA Glycosylase-1 (OGG1). ACS Chem Biol10:2334-43 (2015) [PubMed] Article |
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| More Info.: | Get all data from this article, Assay Method |
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| N-glycosylase/DNA lyase |
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| Name: | N-glycosylase/DNA lyase |
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| Synonyms: | 8-Oxoguanine DNA glycosylase-1 (OGG1) | MMH | MUTM | OGG1 | OGG1_HUMAN | OGH1 |
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| Type: | Protein |
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| Mol. Mass.: | 38794.33 |
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| Organism: | Homo sapiens (Human) |
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| Description: | O15527 |
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| Residue: | 345 |
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| Sequence: | MPARALLPRRMGHRTLASTPALWASIPCPRSELRLDLVLPSGQSFRWREQSPAHWSGVLA
DQVWTLTQTEEQLHCTVYRGDKSQASRPTPDELEAVRKYFQLDVTLAQLYHHWGSVDSHF
QEVAQKFQGVRLLRQDPIECLFSFICSSNNNIARITGMVERLCQAFGPRLIQLDDVTYHG
FPSLQALAGPEVEAHLRKLGLGYRARYVSASARAILEEQGGLAWLQQLRESSYEEAHKAL
CILPGVGTKVADCICLMALDKPQAVPVDVHMWHIAQRDYSWHPTTSQAKGPSPQTNKELG
NFFRSLWGPYAGWAQAVLFSADLRQSRHAQEPPAKRRKGSKGPEG
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| BDBM163681 |
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| n/a |
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| Name | BDBM163681 |
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| Synonyms: | 3-Chloro‐N'‐[(1E)‐(4‐fluorophenyl)methylidene]‐1‐ benzothiophene‐2‐carbohydrazide (0167) |
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| Type | Small organic molecule |
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| Emp. Form. | C16H10ClFN2OS |
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| Mol. Mass. | 332.78 |
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| SMILES | Fc1ccc(\C=N\NC(=O)c2sc3ccccc3c2Cl)cc1 |
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| Structure | 
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