Reaction Details |
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Target | ATP-sensitive inward rectifier potassium channel 1 |
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Ligand | BDBM163850 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Thallium Flux Assay |
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Temperature | 310.15±n/a K |
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IC50 | 400±n/a nM |
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Comments | extracted |
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Citation | Pasternak, A; Blizzard, T; Chobanian, H; de Jesus, R; Ding, F; Dong, S; Gude, C; Kim, D; Tang, H; Walsh, S; Pio, B; Jiang, J Inhibitors of the renal outer medullary potassium channel US Patent US9062070 Publication Date 6/23/2015 |
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More Info.: | Get all data from this article, Assay Method |
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ATP-sensitive inward rectifier potassium channel 1 |
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Name: | ATP-sensitive inward rectifier potassium channel 1 |
Synonyms: | ATP-regulated potassium channel ROM-K | ATP-sensitive inward rectifier potassium channel 1 | Inward rectifier K(+) channel Kir1.1 | KAB-1 | KCNJ1_RAT | Kcnj1 | Potassium channel (ATP modulatory) | Potassium channel, inwardly rectifying subfamily J member 1 | Renal Outer Medullary Potassium (ROMK) | Renal Outer Medullary Potassium (ROMK1) | Romk1 | The Renal Outer Medullary Potassium (ROMK) channel (Kir1.1) |
Type: | Enzyme |
Mol. Mass.: | 44976.27 |
Organism: | Rattus norvegicus (Rat) |
Description: | P35560 |
Residue: | 391 |
Sequence: | MGASERSVFRVLIRALTERMFKHLRRWFITHIFGRSRQRARLVSKEGRCNIEFGNVDAQS
RFIFFVDIWTTVLDLKWRYKMTVFITAFLGSWFLFGLLWYVVAYVHKDLPEFYPPDNRTP
CVENINGMTSAFLFSLETQVTIGYGFRFVTEQCATAIFLLIFQSILGVIINSFMCGAILA
KISRPKKRAKTITFSKNAVISKRGGKLCLLIRVANLRKSLLIGSHIYGKLLKTTITPEGE
TIILDQTNINFVVDAGNENLFFISPLTIYHIIDHNSPFFHMAAETLSQQDFELVVFLDGT
VESTSATCQVRTSYVPEEVLWGYRFVPIVSKTKEGKYRVDFHNFGKTVEVETPHCAMCLY
NEKDARARMKRGYDNPNFVLSEVDETDDTQM
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BDBM163850 |
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n/a |
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Name | BDBM163850 |
Synonyms: | US9062070, 105 | US9062070, 106 |
Type | Small organic molecule |
Emp. Form. | C25H26FN9O |
Mol. Mass. | 487.532 |
SMILES | Cc1c(ccc(F)c1[N+]#[C-])[C@@H]1CN2CCN(C[C@@H]2CN1)C(=O)C1CCc2cc(ncc12)-n1cnnn1 |r| |
Structure |
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