| Reaction Details |
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 | Report a problem with these data |
| Target | Hepatocyte growth factor receptor |
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| Ligand | BDBM24484 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | In Vitro Assay |
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| pH | 8±n/a |
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| Temperature | 300.15±n/a K |
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| Ki | 17.6±n/a nM |
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| Comments | extracted |
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| Citation |  Albrecht, BK; Bauer, D; Bellon, S; Bode, CM; Booker, S; Boezio, A; Choquette, D; D'Amico, D; Harmange, J; Hirai, S; Hungate, RW; Kim, T; Lewis, RT; Liu, L; Lohman, JW; Norman, MH; Potashman, M; Siegmund, AC; Springer, SK; Stec, M; Xi, N; Yang, K Fused heterocyclic derivatives and methods of use US Patent US9066954 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Hepatocyte growth factor receptor |
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| Name: | Hepatocyte growth factor receptor |
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| Synonyms: | Hepatocyte growth factor receptor | Hepatocyte growth factor receptor (MET) | Hepatocyte growth factor receptor (c-MET) | Hepatocyte growth factor receptor (cMET) | MET | MET_HUMAN | Met proto-oncogene (hepatocyte growth factor receptor) | Proto-oncogene c-Met | Tyrosine-protein kinase Met (c-Met) | Tyrosine-protein kinase Met (cMet) | c-Met kinase |
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| Type: | Protein |
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| Mol. Mass.: | 155559.73 |
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| Organism: | Homo sapiens (Human) |
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| Description: | P08581 |
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| Residue: | 1390 |
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| Sequence: | MKAPAVLAPGILVLLFTLVQRSNGECKEALAKSEMNVNMKYQLPNFTAETPIQNVILHEH
HIFLGATNYIYVLNEEDLQKVAEYKTGPVLEHPDCFPCQDCSSKANLSGGVWKDNINMAL
VVDTYYDDQLISCGSVNRGTCQRHVFPHNHTADIQSEVHCIFSPQIEEPSQCPDCVVSAL
GAKVLSSVKDRFINFFVGNTINSSYFPDHPLHSISVRRLKETKDGFMFLTDQSYIDVLPE
FRDSYPIKYVHAFESNNFIYFLTVQRETLDAQTFHTRIIRFCSINSGLHSYMEMPLECIL
TEKRKKRSTKKEVFNILQAAYVSKPGAQLARQIGASLNDDILFGVFAQSKPDSAEPMDRS
AMCAFPIKYVNDFFNKIVNKNNVRCLQHFYGPNHEHCFNRTLLRNSSGCEARRDEYRTEF
TTALQRVDLFMGQFSEVLLTSISTFIKGDLTIANLGTSEGRFMQVVVSRSGPSTPHVNFL
LDSHPVSPEVIVEHTLNQNGYTLVITGKKITKIPLNGLGCRHFQSCSQCLSAPPFVQCGW
CHDKCVRSEECLSGTWTQQICLPAIYKVFPNSAPLEGGTRLTICGWDFGFRRNNKFDLKK
TRVLLGNESCTLTLSESTMNTLKCTVGPAMNKHFNMSIIISNGHGTTQYSTFSYVDPVIT
SISPKYGPMAGGTLLTLTGNYLNSGNSRHISIGGKTCTLKSVSNSILECYTPAQTISTEF
AVKLKIDLANRETSIFSYREDPIVYEIHPTKSFISGGSTITGVGKNLNSVSVPRMVINVH
EAGRNFTVACQHRSNSEIICCTTPSLQQLNLQLPLKTKAFFMLDGILSKYFDLIYVHNPV
FKPFEKPVMISMGNENVLEIKGNDIDPEAVKGEVLKVGNKSCENIHLHSEAVLCTVPNDL
LKLNSELNIEWKQAISSTVLGKVIVQPDQNFTGLIAGVVSISTALLLLLGFFLWLKKRKQ
IKDLGSELVRYDARVHTPHLDRLVSARSVSPTTEMVSNESVDYRATFPEDQFPNSSQNGS
CRQVQYPLTDMSPILTSGDSDISSPLLQNTVHIDLSALNPELVQAVQHVVIGPSSLIVHF
NEVIGRGHFGCVYHGTLLDNDGKKIHCAVKSLNRITDIGEVSQFLTEGIIMKDFSHPNVL
SLLGICLRSEGSPLVVLPYMKHGDLRNFIRNETHNPTVKDLIGFGLQVAKGMKYLASKKF
VHRDLAARNCMLDEKFTVKVADFGLARDMYDKEYYSVHNKTGAKLPVKWMALESLQTQKF
TTKSDVWSFGVLLWELMTRGAPPYPDVNTFDITVYLLQGRRLLQPEYCPDPLYEVMLKCW
HPKAEMRPSFSELVSRISAIFSTFIGEHYVHVNATYVNVKCVAPYPSLLSSEDNADDEVD
TRPASFWETS
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|
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| BDBM24484 |
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| n/a |
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| Name | BDBM24484 |
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| Synonyms: | 4-{[6-(furan-2-yl)-[1,2,4]triazolo[4,3-a]pyridazin-3-yl]methoxy}-7-methoxyquinoline | Triazolopyridazine, 10n | US9066954, 214 |
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| Type | Small organic molecule |
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| Emp. Form. | C20H15N5O3 |
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| Mol. Mass. | 373.3648 |
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| SMILES | COc1ccc2c(OCc3nnc4ccc(nn34)-c3ccco3)ccnc2c1 |
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| Structure | 
|
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