| Reaction Details |
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 | Report a problem with these data |
| Target | NT-3 growth factor receptor |
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| Ligand | BDBM164901 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | Inhibition Assay |
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| IC50 | 0.503±n/a nM |
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| Citation |  Kane, Jr., JL; Matthews, G; Metz, M; Kothe, M; Liu, J; Scholte, A Tropomyosin-related kinase (TRK) inhibitors US Patent US9067914 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| NT-3 growth factor receptor |
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| Name: | NT-3 growth factor receptor |
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| Synonyms: | GP145-TrkC | NTRK3 | NTRK3_HUMAN | Neurotrophic tyrosine kinase receptor | Neurotrophic tyrosine kinase receptor type 3 | TRKC | Trk-C | TrkC tyrosine kinase | Tyrosine kinase receptor C (Trk-C) |
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| Type: | Enzyme |
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| Mol. Mass.: | 94428.15 |
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| Organism: | Homo sapiens (Human) |
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| Description: | Q16288 |
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| Residue: | 839 |
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| Sequence: | MDVSLCPAKCSFWRIFLLGSVWLDYVGSVLACPANCVCSKTEINCRRPDDGNLFPLLEGQ
DSGNSNGNASINITDISRNITSIHIENWRSLHTLNAVDMELYTGLQKLTIKNSGLRSIQP
RAFAKNPHLRYINLSSNRLTTLSWQLFQTLSLRELQLEQNFFNCSCDIRWMQLWQEQGEA
KLNSQNLYCINADGSQLPLFRMNISQCDLPEISVSHVNLTVREGDNAVITCNGSGSPLPD
VDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSEDNGFTLTCIAENVVGMSNASVALT
VYYPPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQPLRESKIIHVEYYQEGEISE
GCLLFNKPTHYNNGNYTLIAKNPLGTANQTINGHFLKEPFPESTDNFILFDEVSPTPPIT
VTHKPEEDTFGVSIAVGLAAFACVLLVVLFVMINKYGRRSKFGMKGPVAVISGEEDSASP
LHHINHGITTPSSLDAGPDTVVIGMTRIPVIENPQYFRQGHNCHKPDTYVQHIKRRDIVL
KRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAARKDFQREAELLTNLQHEHI
VKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILVDGQPRQAKGELGLSQMLHIA
SQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGMSRDVYSTDYYRLFNPSGNDF
CIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQLSNTEVI
ECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALGKATPIYLDILG
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| BDBM164901 |
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| n/a |
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| Name | BDBM164901 |
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| Synonyms: | US10166239, Ex. 3-15 | US11406644, Example 3-15 | US9067914, Ex. 3-15 |
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| Type | Small organic molecule |
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| Emp. Form. | C26H26N6O3 |
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| Mol. Mass. | 470.523 |
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| SMILES | COc1ccc(COc2ccc(Cn3c(N)nc4cc(cnc34)-c3cnn(C)c3)cc2OC)cc1 |
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| Structure | 
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