| Reaction Details |
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 | Report a problem with these data |
| Target | Beta-secretase 2 |
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| Ligand | BDBM165908 |
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| Substrate/Competitor | n/a |
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| Meas. Tech. | ELISA Assay |
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| IC50 | 79±n/a nM |
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| Citation |  Hilpert, H; Rogers-Evans, M; Rombach, D 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors US Patent US9067924 Publication Date 6/30/2015 |
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| More Info.: | Get all data from this article, Assay Method |
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| Beta-secretase 2 |
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| Name: | Beta-secretase 2 |
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| Synonyms: | BACE2_MOUSE | Bace2 | Beta-secretase 2 (BACE2) |
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| Type: | Enzyme |
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| Mol. Mass.: | 55787.27 |
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| Organism: | Mus musculus (Mouse) |
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| Description: | Q9JL18 |
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| Residue: | 514 |
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| Sequence: | MGALLRALLLLVLAQWLLSAVPALAPAPFTLPLQVAGATNHRASAVPGLGTPELPRADGL
ALALEPVRATANFLAMVDNLQGDSGRGYYLEMLIGTPPQKVQILVDTGSSNFAVAGAPHS
YIDTYFDSESSSTYHSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNSSFLVNIATIFESE
NFFLPGIKWNGILGLAYAALAKPSSSLETFFDSLVAQAKIPDIFSMQMCGAGLPVAGSGT
NGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQNLNLDCREYNADKAIVDS
GTTLLRLPQKVFDAVVEAVARTSLIPEFSDGFWTGAQLACWTNSETPWAYFPKISIYLRD
ENASRSFRITILPQLYIQPMMGAGFNYECYRFGISSSTNALVIGATVMEGFYVVFDRAQR
RVGFAVSPCAEIEGTTVSEISGPFSTEDIASNCVPAQALNEPILWIVSYALMSVCGAILL
VLILLLLLPLHCRHAPRDPEVVNDESSLVRHRWK
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| BDBM165908 |
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| n/a |
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| Name | BDBM165908 |
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| Synonyms: | US9067924, 2 |
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| Type | Small organic molecule |
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| Emp. Form. | C18H18F2N4OS |
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| Mol. Mass. | 376.424 |
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| SMILES | C[C@]1(CCSCC(N)=N1)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:7| |
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| Structure | 
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