Reaction Details |
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Target | Beta-secretase 1 |
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Ligand | BDBM165915 |
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Substrate/Competitor | n/a |
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Meas. Tech. | ELISA Assay |
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IC50 | 300±n/a nM |
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Citation | Hilpert, H; Rogers-Evans, M; Rombach, D 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors US Patent US9067924 Publication Date 6/30/2015 |
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More Info.: | Get all data from this article, Assay Method |
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Beta-secretase 1 |
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Name: | Beta-secretase 1 |
Synonyms: | BACE1_MOUSE | Bace | Bace1 | Beta-secretase 1 | Beta-secretase 1 (BACE1) |
Type: | Enzyme |
Mol. Mass.: | 55739.56 |
Organism: | Mus musculus (Mouse) |
Description: | P56818 |
Residue: | 501 |
Sequence: | MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
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BDBM165915 |
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n/a |
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Name | BDBM165915 |
Synonyms: | US9067924, 9 |
Type | Small organic molecule |
Emp. Form. | C17H19ClFN5O3S |
Mol. Mass. | 427.881 |
SMILES | CC1C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2[nH]ncc2Cl)ccc1F |r,c:3| |
Structure |
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