| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Beta-secretase 1 |
|---|
| Ligand | BDBM165916 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | ELISA Assay |
|---|
| IC50 | 62±n/a nM |
|---|
| Citation |  Hilpert, H; Rogers-Evans, M; Rombach, D 1,4 thiazepines/sulfones as BACE1 and/or BACE2 inhibitors US Patent US9067924 Publication Date 6/30/2015 |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Beta-secretase 1 |
|---|
| Name: | Beta-secretase 1 |
|---|
| Synonyms: | BACE1_MOUSE | Bace | Bace1 | Beta-secretase 1 | Beta-secretase 1 (BACE1) |
|---|
| Type: | Enzyme |
|---|
| Mol. Mass.: | 55739.56 |
|---|
| Organism: | Mus musculus (Mouse) |
|---|
| Description: | P56818 |
|---|
| Residue: | 501 |
|---|
| Sequence: | MAPALHWLLLWVGSGMLPAQGTHLGIRLPLRSGLAGPPLGLRLPRETDEESEEPGRRGSF
VEMVDNLRGKSGQGYYVEMTVGSPPQTLNILVDTGSSNFAVGAAPHPFLHRYYQRQLSST
YRDLRKGVYVPYTQGKWEGELGTDLVSIPHGPNVTVRANIAAITESDKFFINGSNWEGIL
GLAYAEIARPDDSLEPFFDSLVKQTHIPNIFSLQLCGAGFPLNQTEALASVGGSMIIGGI
DHSLYTGSLWYTPIRREWYYEVIIVRVEINGQDLKMDCKEYNYDKSIVDSGTTNLRLPKK
VFEAAVKSIKAASSTEKFPDGFWLGEQLVCWQAGTTPWNIFPVISLYLMGEVTNQSFRIT
ILPQQYLRPVEDVATSQDDCYKFAVSQSSTGTVMGAVIMEGFYVVFDRARKRIGFAVSAC
HVHDEFRTAAVEGPFVTADMEDCGYNIPQTDESTLMTIAYVMAAICALFMLPLCLMVCQW
RCLRCLRHQHDDFADDISLLK
|
|
|
|---|
| BDBM165916 |
|---|
| n/a |
|---|
| Name | BDBM165916 |
|---|
| Synonyms: | US9067924, 10 |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H22F2N4O3S |
|---|
| Mol. Mass. | 436.475 |
|---|
| SMILES | CC1(C)C(N)=N[C@@](C)(CCS1(=O)=O)c1cc(NC(=O)c2ccc(F)cn2)ccc1F |r,c:4| |
|---|
| Structure | 
|
|---|
Search and Browse
