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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM166069 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 1±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
| ||
| BDBM166069 | |||
| n/a | |||
| Name | BDBM166069 | ||
| Synonyms: | US9067937, 12 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C24H28Cl2N4O3S | ||
| Mol. Mass. | 523.475 | ||
| SMILES | CN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)S(C)(=O)=O |r,wU:7.10,wD:4.3,(-4,5,;-2.67,4.23,;-1.33,5,;-2.67,2.69,;-1.33,1.93,;-1.33,.38,;,-.38,;1.33,.38,;1.33,1.93,;,2.69,;2.67,-.38,;2.67,-1.93,;4,-2.69,;4,-4.23,;2.67,-5,;1.33,-4.23,;,-5,;-1.33,-4.23,;-1.33,-2.69,;,-1.93,;1.33,-2.69,;-2.67,-1.93,;-2.67,-.38,;-4,.38,;-4,1.93,;-5.33,-.38,;-6.67,.38,;-5.33,-1.93,;-6.67,-2.69,;-4,-2.69,;5.33,-1.93,;6.67,-2.69,;6.1,-.59,;4.56,-.59,)| | ||
| Structure | 
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