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TargetMaternal embryonic leucine zipper kinase
LigandBDBM166100
Substrate/Competitorn/a
Meas. Tech.Kinase Assay
pH7.4±n/a
Temperature298.15±n/a K
IC50 0.3±n/a nM
Commentsextracted
Citation Matsuo, YHisada, SNakamura, YAhmed, FWalker, JRHuntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015
More Info.:Get all data from this article,  Assay Method
 
Maternal embryonic leucine zipper kinase
Name:Maternal embryonic leucine zipper kinase
Synonyms:KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK)
Type:Enzyme
Mol. Mass.:74665.45
Organism:Homo sapiens (Human)
Description:Q14680
Residue:651
Sequence:
MKDYDELLKYYELHETIGTGGFAKVKLACHILTGEMVAIKIMDKNTLGSDLPRIKTEIEA
LKNLRHQHICQLYHVLETANKIFMVLEYCPGGELFDYIISQDRLSEEETRVVFRQIVSAV
AYVHSQGYAHRDLKPENLLFDEYHKLKLIDFGLCAKPKGNKDYHLQTCCGSLAYAAPELI
QGKSYLGSEADVWSMGILLYVLMCGFLPFDDDNVMALYKKIMRGKYDVPKWLSPSSILLL
QQMLQVDPKKRISMKNLLNHPWIMQDYNYPVEWQSKNPFIHLDDDCVTELSVHHRNNRQT
MEDLISLWQYDHLTATYLLLLAKKARGKPVRLRLSSFSCGQASATPFTDIKSNNWSLEDV
TASDKNYVAGLIDYDWCEDDLSTGAATPRTSQFTKYWTESNGVESKSLTPALCRTPANKL
KNKENVYTPKSAVKNEEYFMFPEPKTPVNKNQHKREILTTPNRYTTPSKARNQCLKETPI
KIPVNSTGTDKLMTGVISPERRCRSVELDLNQAHMEETPKRKGAKVFGSLERGLDKVITV
LTRSKRKGSARDGPRRLKLHYNVTTTRLVNPDQLLNEIMSILPKKHVDFVQKGYTLKCQT
QSDFGKVTMQFELEVCQLQKPDVVGIRRQRLKGDAWVYKRLVEDILSSCKV
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  Blast E-value cutoff:
BDBM166100
n/a
NameBDBM166100
Synonyms:US9067937, 44
TypeSmall organic molecule
Emp. Form.C25H28Cl2N4O3
Mol. Mass.503.421
SMILESCN(C)C[C@H]1CC[C@@H](CC1)Nc1c(cnc2ccc(nc12)-c1cc(Cl)c(O)c(Cl)c1)C(=O)CO |r,wU:7.10,wD:4.3,(-4.67,5,;-3.33,4.23,;-2,5,;-3.33,2.69,;-2,1.93,;-2,.38,;-.67,-.38,;.67,.38,;.67,1.93,;-.67,2.69,;2,-.38,;2,-1.93,;3.33,-2.69,;3.33,-4.23,;2,-5,;.67,-4.23,;-.67,-5,;-2,-4.23,;-2,-2.69,;-.67,-1.93,;.67,-2.69,;-3.33,-1.93,;-3.33,-.38,;-4.67,.38,;-4.67,1.93,;-6,-.38,;-7.34,.38,;-6,-1.93,;-7.34,-2.69,;-4.67,-2.69,;4.67,-1.93,;4.67,-.38,;6,-2.69,;7.34,-1.93,)|
Structure
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