Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Maternal embryonic leucine zipper kinase | ||
Ligand | BDBM166118 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Kinase Assay | ||
pH | 7.4±n/a | ||
Temperature | 298.15±n/a K | ||
IC50 | 0.9±n/a nM | ||
Comments | extracted | ||
Citation | Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Maternal embryonic leucine zipper kinase | |||
Name: | Maternal embryonic leucine zipper kinase | ||
Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
Type: | Enzyme | ||
Mol. Mass.: | 74665.45 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q14680 | ||
Residue: | 651 | ||
Sequence: |
| ||
BDBM166118 | |||
n/a | |||
Name | BDBM166118 | ||
Synonyms: | US9067937, 62 | ||
Type | Small organic molecule | ||
Emp. Form. | C27H30ClFN4O2 | ||
Mol. Mass. | 497.004 | ||
SMILES | CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN2CCCC2)CC1)-c1cc(F)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.67,-3.49,;5.33,-2.72,;5.33,-1.18,;4,-3.49,;4,-5.03,;2.67,-5.8,;1.33,-5.03,;,-5.8,;-1.33,-5.03,;-1.33,-3.49,;,-2.72,;1.33,-3.49,;2.67,-2.72,;2.67,-1.18,;1.33,-.41,;1.33,1.13,;,1.9,;-1.33,1.13,;-2.67,1.9,;-2.67,3.44,;-1.42,4.34,;-1.9,5.8,;-3.44,5.8,;-3.91,4.34,;-1.33,-.41,;,-1.18,;-2.67,-2.72,;-4,-3.49,;-5.33,-2.72,;-6.67,-3.49,;-5.33,-1.18,;-6.67,-.41,;-4,-.41,;-4,1.13,;-2.67,-1.18,)| | ||
Structure |