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| Reaction Details | |||
|---|---|---|---|
 | Report a problem with these data | ||
| Target | Maternal embryonic leucine zipper kinase | ||
| Ligand | BDBM166126 | ||
| Substrate/Competitor | n/a | ||
| Meas. Tech. | Kinase Assay | ||
| pH | 7.4±n/a | ||
| Temperature | 298.15±n/a K | ||
| IC50 | 0.6±n/a nM | ||
| Comments | extracted | ||
| Citation |  Matsuo, Y; Hisada, S; Nakamura, Y; Ahmed, F; Walker, JR; Huntley, R 1,5-naphthyridine derivatives and MELK inhibitors containing the same US Patent US9067937 Publication Date 6/30/2015 | ||
| More Info.: | Get all data from this article, Assay Method | ||
| Maternal embryonic leucine zipper kinase | |||
| Name: | Maternal embryonic leucine zipper kinase | ||
| Synonyms: | KIAA0175 | MELK | MELK_HUMAN | Maternal embryonic leucine zipper kinase | Maternal embryonic leucine zipper kinase (MELK) | ||
| Type: | Enzyme | ||
| Mol. Mass.: | 74665.45 | ||
| Organism: | Homo sapiens (Human) | ||
| Description: | Q14680 | ||
| Residue: | 651 | ||
| Sequence: |
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| BDBM166126 | |||
| n/a | |||
| Name | BDBM166126 | ||
| Synonyms: | US9067937, 70 | ||
| Type | Small organic molecule | ||
| Emp. Form. | C27H31Cl2N5O2 | ||
| Mol. Mass. | 528.473 | ||
| SMILES | CC(=O)c1cnc2ccc(nc2c1N[C@H]1CC[C@H](CN2CCNCC2)CC1)-c1cc(Cl)c(O)c(Cl)c1 |r,wU:17.19,wD:14.15,(6.67,-3.85,;5.33,-3.08,;5.33,-1.54,;4,-3.85,;4,-5.39,;2.67,-6.16,;1.33,-5.39,;,-6.16,;-1.33,-5.39,;-1.33,-3.85,;,-3.08,;1.33,-3.85,;2.67,-3.08,;2.67,-1.54,;1.33,-.77,;1.33,.77,;,1.54,;-1.33,.77,;-2.67,1.54,;-2.67,3.08,;-1.33,3.85,;-1.33,5.39,;-2.67,6.16,;-4,5.39,;-4,3.85,;-1.33,-.77,;,-1.54,;-2.67,-3.08,;-2.67,-1.54,;-4,-.77,;-4,.77,;-5.33,-1.54,;-6.67,-.77,;-5.33,-3.08,;-6.67,-3.85,;-4,-3.85,)| | ||
| Structure | 
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