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TargetNitric Oxide Synthase, inducible
LigandBDBM166688
Substrate/Competitorn/a
Meas. Tech.iNOS Activity Assay
Ki 6.2e+3± 1.6e+3 nM
Citation Oliveira BLMorais MMendes FMoreira ISCordeiro CFernandes PARamos MJAlberto RSantos ICorreia JD Re(I) and Tc(I) complexes for targeting nitric oxide synthase: influence of the chelator in the affinity for the enzyme. Chem Biol Drug Des 86:1072-86 (2015) [PubMed]  Article
More Info.:Get all data from this article,  Assay Method
 
Nitric Oxide Synthase, inducible
Name:Nitric oxide synthase, inducible
Synonyms:Inducible NO synthase | Inducible NOS | Inducible nitric oxide synthase (iNOS) | MAC-NOS | Macrophage NOS | NOS type II | Nitric oxide synthase, inducible (iNOS)
Type:Enzyme
Mol. Mass.:130595.79
Organism:Mus musculus (mouse)
Description:Recombinant enzyme overexpressed in E. coli.
Residue:1144
Sequence:
MACPWKFLFKVKSYQSDLKEEKDINNNVKKTPCAVLSPTIQDDPKSHQNGSPQLLTGTAQ
NVPESLDKLHVTSTRPQYVRIKNWGSGEILHDTLHHKATSDFTCKSKSCLGSIMNPKSLT
RGPRDKPTPLEELLPHAIEFINQYYGSFKEAKIEEHLARLEAVTKEIETTGTYQLTLDEL
IFATKMAWRNAPRCIGRIQWSNLQVFDARNCSTAQEMFQHICRHILYATNNGNIRSAITV
FPQRSDGKHDFRLWNSQLIRYAGYQMPDGTIRGDAATLEFTQLCIDLGWKPRYGRFDVLP
LVLQADGQDPEVFEIPPDLVLEVTMEHPKYEWFQELGLKWYALPAVANMLLEVGGLEFPA
CPFNGWYMGTEIGVRDFCDTQRYNILEEVGRRMGLETHTLASLWKDRAVTEINVAVLHSF
QKQNVTIMDHHTASESFMKHMQNEYRARGGCPADWIWLVPPVSGSITPVFHQEMLNYVLS
PFYYYQIEPWKTHIWQNEKLRPRRREIRFRVLVKVVFFASMLMRKVMASRVRATVLFATE
TGKSEALARDLATLFSYAFNTKVVCMDQYKASTLEEEQLLLVVTSTFGNGDCPSNGQTLK
KSLFMLRELNHTFRYAVFGLGSSMYPQFCAFAHDIDQKLSHLGASQLAPTGEGDELSGQE
DAFRSWAVQTFRAACETFDVRSKHHIQIPKRFTSNATWEPQQYRLIQSPEPLDLNRALSS
IHAKNVFTMRLKSQQNLQSEKSSRTTLLVQLTFEGSRGPSYLPGEHLGIFPGNQTALVQG
ILERVVDCPTPHQTVCLEVLDESGSYWVKDKRLPPCSLSQALTYFLDITTPPTQLQLHKL
ARFATDETDRQRLEALCQPSEYNDWKFSNNPTFLEVLEEFPSLHVPAAFLLSQLPILKPR
YYSISSSQDHTPSEVHLTVAVVTYRTRDGQGPLHHGVCSTWIRNLKPQDPVPCFVRSVSG
FQLPEDPSQPCILIGPGTGIAPFRSFWQQRLHDSQHKGLKGGRMSLVFGCRHPEEDHLYQ
EEMQEMVRKRVLFQVHTGYSRLPGKPKVYVQDILQKQLANEVLSVLHGEQGHLYICGDVR
MARDVATTLKKLVATKLNLSEEQVEDYFFQLKSQKRYHEDIFGAVFSYGAKKGSALEEPK
ATRL
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM166688
n/a
NameBDBM166688
Synonyms:2-Amino-2-(aminomethyl)-6-(1-carboxy-4-(2-nitroguanidino)butylamino)-6-oxohexanoic acid (L5)
TypeSmall organic molecule
Emp. Form.C13H25N7O7
Mol. Mass.391.3803
SMILESNCC(N)(CCCC(=O)NC(CCCNC(N)=N[N+]([O-])=O)C(O)=O)C(O)=O |w:17.17|
Structure
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