| Reaction Details |
|---|
 | Report a problem with these data |
| Target | Dipeptidyl peptidase 4 [K6R,T557I] |
|---|
| Ligand | BDBM167938 |
|---|
| Substrate/Competitor | n/a |
|---|
| Meas. Tech. | DPP-IV Inhibition Activity |
|---|
| Temperature | 298.15±n/a K |
|---|
| IC50 | 15±0.0 nM |
|---|
| Comments | extracted |
|---|
| Citation |  Gomha, SM; Eldebss, TM; Badrey, MG; Abdulla, MM; Mayhoub, AS Novel 4-heteroaryl-antipyrines as DPP-IV inhibitors. Chem Biol Drug Des86:1292-303 (2015) [PubMed] Article |
|---|
| More Info.: | Get all data from this article, Assay Method |
|---|
| |
| Dipeptidyl peptidase 4 [K6R,T557I] |
|---|
| Name: | Dipeptidyl peptidase 4 [K6R,T557I] |
|---|
| Synonyms: | ADCP2 | CD26 | DPP4 | DPP4_HUMAN | Dipeptidyl peptidase IV (DPP-IV) | Dipeptidyl peptidase-IV (DDP-4) | Dipeptidyl peptidase-IV (DPP-IV) |
|---|
| Type: | Protein |
|---|
| Mol. Mass.: | 88325.11 |
|---|
| Organism: | Homo sapiens (Human) |
|---|
| Description: | P27487[K6R,T557I] |
|---|
| Residue: | 766 |
|---|
| Sequence: | MKTPWRVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSL
RWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNY
VKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNL
PSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSF
YSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYL
CDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPS
EPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISN
EYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLY
TLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKY
PLLLDVYAGPCSQKADIVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGT
FEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWE
YYESVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQIS
KALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP
|
|
|
|---|
| BDBM167938 |
|---|
| n/a |
|---|
| Name | BDBM167938 |
|---|
| Synonyms: | 1',5'-Dimethyl-2'-phenyl-5-(phenylsulfonyl)-1'H,2H-[3,4'-bipyrazol]-3'(2'H)-one (18) |
|---|
| Type | Small organic molecule |
|---|
| Emp. Form. | C20H18N4O3S |
|---|
| Mol. Mass. | 394.447 |
|---|
| SMILES | Cc1c(-c2cc(n[nH]2)S(=O)(=O)c2ccccc2)c(=O)n(-c2ccccc2)n1C |
|---|
| Structure | 
|
|---|
Search and Browse
