Reaction Details |
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Target | Sodium-dependent dopamine transporter |
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Ligand | BDBM287960 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Assay for Dopamine Reuptake Inhibition |
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pH | 7.4±n/a |
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EC50 | 18.0±7 nM |
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Comments | extracted |
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Citation | Ananthan, S; Rothman, RB Quinazolines as biogenic amine transport modulators US Patent US10087148 Publication Date 10/2/2018 |
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More Info.: | Get all data from this article, Assay Method |
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Sodium-dependent dopamine transporter |
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Name: | Sodium-dependent dopamine transporter |
Synonyms: | DA transporter | DAT | DAT1 | Dopamine transporter (DAT) | Dopamine transporter protein (DAT) | Monoamine transporter | SC6A3_HUMAN | SLC6A3 | Sodium-dependent dopamine transporter | Sodium-dependent dopamine transporter (DAT) | Solute carrier family 6 member 3 |
Type: | Multi-pass membrane protein |
Mol. Mass.: | 68497.11 |
Organism: | Homo sapiens (Human) |
Description: | Q01959 |
Residue: | 620 |
Sequence: | MSKSKCSVGLMSSVVAPAKEPNAVGPKEVELILVKEQNGVQLTSSTLTNPRQSPVEAQDR
ETWGKKIDFLLSVIGFAVDLANVWRFPYLCYKNGGGAFLVPYLLFMVIAGMPLFYMELAL
GQFNREGAAGVWKICPILKGVGFTVILISLYVGFFYNVIIAWALHYLFSSFTTELPWIHC
NNSWNSPNCSDAHPGDSSGDSSGLNDTFGTTPAAEYFERGVLHLHQSHGIDDLGPPRWQL
TACLVLVIVLLYFSLWKGVKTSGKVVWITATMPYVVLTALLLRGVTLPGAIDGIRAYLSV
DFYRLCEASVWIDAATQVCFSLGVGFGVLIAFSSYNKFTNNCYRDAIVTTSINSLTSFSS
GFVVFSFLGYMAQKHSVPIGDVAKDGPGLIFIIYPEAIATLPLSSAWAVVFFIMLLTLGI
DSAMGGMESVITGLIDEFQLLHRHRELFTLFIVLATFLLSLFCVTNGGIYVFTLLDHFAA
GTSILFGVLIEAIGVAWFYGVGQFSDDIQQMTGQRPSLYWRLCWKLVSPCFLLFVVVVSI
VTFRPPHYGAYIFPDWANALGWVIATSSMAMVPIYAAYKFCSLPGSFREKLAYAIAPEKD
RELVDRGEVRQFTLRHWLKV
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BDBM287960 |
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n/a |
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Name | BDBM287960 |
Synonyms: | (5-(2-((2-(4-(dimethylamino)-2- methylphenyl)quinazolin-4-yl)amino)- 1-phenylethyl)-1H-pyrrol-2- yl)methanol | US10087148, Example 28 |
Type | Small organic molecule |
Emp. Form. | C30H31N5O |
Mol. Mass. | 477.6 |
SMILES | CN(C)c1ccc(c(C)c1)-c1nc(NCC(c2ccc(CO)[nH]2)c2ccccc2)c2ccccc2n1 |
Structure |
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