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Targetvon Hippel-Lindau disease tumor suppressor
LigandBDBM171826
Substrate/Competitorn/a
Meas. Tech.Inhibition Assay
pH7.5±n/a
IC50 1500±0 nM
Commentsextracted
Citation Flamme, IErgüden, JOehme, FThede, KKarig, GKuhl, AWild, HSchuhmacher, JKolkhof, PBärfacker, LHütter, J 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases US Patent US9085572 Publication Date 7/21/2015
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von Hippel-Lindau disease tumor suppressor
Name:von Hippel-Lindau disease tumor suppressor
Synonyms:Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL
Type:Protein
Mol. Mass.:24136.87
Organism:Homo sapiens (Human)
Description:P40337
Residue:213
Sequence:
MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
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  Blast E-value cutoff:
BDBM171826
n/a
NameBDBM171826
Synonyms:US9085572, 43
Typen/a
Emp. Form.C14H12N4O2
Mol. Mass.268.2707
SMILESOCc1ccnc(c1)-n1[nH]cc(-c2cccnc2)c1=O
Structure
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