Reaction Details |
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Target | von Hippel-Lindau disease tumor suppressor |
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Ligand | BDBM171830 |
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Substrate/Competitor | n/a |
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Meas. Tech. | Inhibition Assay |
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pH | 7.5±n/a |
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IC50 | 1900±0 nM |
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Comments | extracted |
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Citation | Flamme, I; Ergüden, J; Oehme, F; Thede, K; Karig, G; Kuhl, A; Wild, H; Schuhmacher, J; Kolkhof, P; Bärfacker, L; Hütter, J 4-(pyridin-3-yl)-2(pyridin-2yl)-1,2-dihydro-3H-pyrazol-3-one derivatives as specific HIF-pyrolyl-4-hydroxylase inhibitors for treating cardiovascular and haematological diseases US Patent US9085572 Publication Date 7/21/2015 |
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More Info.: | Get all data from this article, Assay Method |
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von Hippel-Lindau disease tumor suppressor |
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Name: | von Hippel-Lindau disease tumor suppressor |
Synonyms: | Protein G7 | VHL | VHL_HUMAN | Von Hippel-Lindau disease tumor suppressor | Von Hippel-Lindau disease tumor suppressor protein (VBC) | pVHL |
Type: | Protein |
Mol. Mass.: | 24136.87 |
Organism: | Homo sapiens (Human) |
Description: | P40337 |
Residue: | 213 |
Sequence: | MPRRAENWDEAEVGAEEAGVEEYGPEEDGGEESGAEESGPEESGPEELGAEEEMEAGRPR
PVLRSVNSREPSQVIFCNRSPRVVLPVWLNFDGEPQPYPTLPPGTGRRIHSYRGHLWLFR
DAGTHDGLLVNQTELFVPSLNVDGQPIFANITLPVYTLKERCLQVVRSLVKPENYRRLDI
VRSLYEDLEDHPNVQKDLERLTQERIAHQRMGD
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BDBM171830 |
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n/a |
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Name | BDBM171830 |
Synonyms: | US9085572, 50 |
Type | n/a |
Emp. Form. | C20H18ClN7O2 |
Mol. Mass. | 423.856 |
SMILES | Clc1cnn(CCC(=O)NCc2ccnc(c2)-n2[nH]cc(-c3cccnc3)c2=O)c1 |
Structure |
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