Reaction Details | |||
---|---|---|---|
Report a problem with these data | |||
Target | Histone-lysine N-methyltransferase EZH2 | ||
Ligand | BDBM172140 | ||
Substrate/Competitor | n/a | ||
Meas. Tech. | Enzyme Assay | ||
Temperature | 298.15±n/a K | ||
IC50 | 3.44±n/a nM | ||
Comments | extracted | ||
Citation | Kuntz, KW; Chesworth, R; Duncan, KW; Keilhack, H; Warholic, N; Klaus, C; Knutson, SK; Wigle, TJ; Seki, M; Shirotori, S; Kawano, S Aryl- or heteroaryl-substituted benzene compounds US Patent US9090562 Publication Date 7/28/2015 | ||
More Info.: | Get all data from this article, Assay Method | ||
Histone-lysine N-methyltransferase EZH2 | |||
Name: | Histone-lysine N-methyltransferase EZH2 | ||
Synonyms: | ENX-1 | EZH2 | EZH2_HUMAN | Enhancer of zeste homolog 2 (EZH2) | Histone-lysine N-methyltransferase EZH2 | KMT6 | Lysine N-methyltransferase 6 | ||
Type: | Protein | ||
Mol. Mass.: | 85367.84 | ||
Organism: | Homo sapiens (Human) | ||
Description: | Q15910 | ||
Residue: | 746 | ||
Sequence: |
| ||
BDBM172140 | |||
n/a | |||
Name | BDBM172140 | ||
Synonyms: | US10155002, Compound 147 | US11052093, Compound 147 | US9090562, 147 | ||
Type | Small organic molecule | ||
Emp. Form. | C32H42N4O2 | ||
Mol. Mass. | 514.7015 | ||
SMILES | CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccccc1 |r,wU:3.2,wD:6.9,(-2,5,;-3.33,4.23,;-3.33,2.69,;-4.67,1.93,;-4.67,.38,;-6,-.38,;-7.34,.38,;-7.34,1.93,;-6,2.69,;-8.67,-.38,;-10,.38,;-8.67,-1.93,;-2,1.93,;-2,.38,;-.67,-.38,;.67,.38,;.67,1.93,;2,2.69,;2,4.23,;3.33,1.93,;4.67,2.69,;6,1.93,;7.34,2.69,;7.34,4.23,;8.67,1.93,;8.67,.38,;10,-.38,;7.34,-.38,;6,.38,;4.67,-.38,;-.67,2.69,;-.67,4.23,;-.67,-1.93,;-2,-2.69,;-2,-4.23,;-.67,-5,;.67,-4.23,;.67,-2.69,)| | ||
Structure |