Ki Summary BindingDB logo
myBDB logout
Reaction Details
Report a problem with these data
TargetHistone-lysine N-methyltransferase EZH2 [Y641F]
LigandBDBM172038
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature298.15±n/a K
IC50 11.07±n/a nM
Commentsextracted
Citation Kuntz, KWChesworth, RDuncan, KWKeilhack, HWarholic, NKlaus, CKnutson, SKWigle, TJSeki, MShirotori, SKawano, S Aryl- or heteroaryl-substituted benzene compounds US Patent US9090562 Publication Date 7/28/2015
More Info.:Get all data from this article,  Assay Method
 
Histone-lysine N-methyltransferase EZH2 [Y641F]
Name:Histone-lysine N-methyltransferase EZH2 [Y641F]
Synonyms:EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6
Type:n/a
Mol. Mass.:85351.84
Organism:Homo sapiens (Human)
Description:Q15910[Y641F]
Residue:746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
Blast this sequence in BindingDB or PDB
  Blast E-value cutoff:
BDBM172038
n/a
NameBDBM172038
Synonyms:US10155002, Compound 44 | US10647700, Compound EPZ6438 | US11052093, Compound 143 | US11535629, Compound Control A | US9090562, 143 | US9090562, 44 | US9394283, 1
TypeSmall organic molecule
Emp. Form.C34H44N4O4
Mol. Mass.572.7376
SMILESCCN(C1CCOCC1)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(CN2CCOCC2)cc1
Structure
Search PDB for entries with ligand similarity:Similarity to this molecule at least: