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TargetEZH2(Y641F)
LigandBDBM172162
Substrate/Competitorn/a
Meas. Tech.Enzyme Assay
Temperature298.15±n/a K
IC50 1.63±n/a nM
Commentsextracted
Citation Kuntz KWChesworth RDuncan KWKeilhack HWarholic NKlaus CKnutson SKWigle TJSeki MShirotori SKawano S Aryl- or heteroaryl-substituted benzene compounds US Patent  US9090562 Publication Date 7/28/2015
More Info.:Get all data from this article,  Assay Method
 
EZH2(Y641F)
Name:EZH2(Y641F)
Synonyms:Histone-lysine N-methyltransferase EZH2 (Y641F)
Type:n/a
Mol. Mass.:85351.84
Organism:Homo sapiens (Human)
Description:TL
Residue:746
Sequence:
MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP
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  Blast E-value cutoff:
BDBM172162
n/a
NameBDBM172162
Synonyms:US10155002, Compound 170 | US9090562, 170
TypeSmall organic molecule
Emp. Form.C36H51N7O2
Mol. Mass.613.8358
SMILESCCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCN(C)CC1 |r,wU:3.2,wD:6.9,(3.47,8,;2.69,6.67,;3.47,5.33,;5,5.33,;5.78,6.67,;7.31,6.67,;8.08,5.33,;7.31,4,;5.78,4,;9.63,5.33,;10.39,6.67,;10.39,4,;2.69,4,;1.15,4,;.38,2.67,;1.15,1.33,;2.69,1.33,;3.47,,;5,,;2.69,-1.33,;3.47,-2.67,;2.69,-4,;3.47,-5.33,;5,-5.33,;2.69,-6.67,;1.15,-6.67,;.38,-8,;.38,-5.33,;1.15,-4,;.38,-2.67,;3.47,2.67,;5,2.67,;-1.15,2.67,;-1.93,4,;-3.47,4,;-4.23,2.67,;-3.47,1.33,;-1.93,1.33,;-5.78,2.67,;-6.54,4,;-8.08,4,;-8.85,2.67,;-10.39,2.67,;-8.08,1.33,;-6.54,1.33,)|
Structure
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