Ki Summary

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Target

Histone-lysine N-methyltransferase EZH2 [Y641F]

Ligand

BDBM172164

Substrate/Competitor

n/a

Meas. Tech.

Enzyme Assay

Temperature

298.15±n/a K

IC50

4.21±n/a nM

Comments

extracted

Citation

Kuntz, KW; Chesworth, R; Duncan, KW; Keilhack, H; Warholic, N; Klaus, C; Knutson, SK; Wigle, TJ; Seki, M; Shirotori, S; Kawano, S Aryl- or heteroaryl-substituted benzene compounds US Patent US9090562 Publication Date 7/28/2015

More Info.:

Get all data from this article, Assay Method

Histone-lysine N-methyltransferase EZH2 [Y641F]

Name:

Histone-lysine N-methyltransferase EZH2 [Y641F]

Synonyms:

EZH2 | EZH2(Y641F) | EZH2_HUMAN | Histone-lysine N-methyltransferase EZH2 (Y641F) | KMT6

Type:

n/a

Mol. Mass.:

85351.84

Organism:

Homo sapiens (Human)

Description:

Q15910[Y641F]

Residue:

746

Sequence:

MGQTGKKSEKGPVCWRKRVKSEYMRLRQLKRFRRADEVKSMFSSNRQKILERTEILNQEW
KQRRIQPVHILTSVSSLRGTRECSVTSDLDFPTQVIPLKTLNAVASVPIMYSWSPLQQNF
MVEDETVLHNIPYMGDEVLDQDGTFIEELIKNYDGKVHGDRECGFINDEIFVELVNALGQ
YNDDDDDDDGDDPEEREEKQKDLEDHRDDKESRPPRKFPSDKIFEAISSMFPDKGTAEEL
KEKYKELTEQQLPGALPPECTPNIDGPNAKSVQREQSLHSFHTLFCRRCFKYDCFLHPFH
ATPNTYKRKNTETALDNKPCGPQCYQHLEGAKEFAAALTAERIKTPPKRPGGRRRGRLPN
NSSRPSTPTINVLESKDTDSDREAGTETGGENNDKEEEEKKDETSSSSEANSRCQTPIKM
KPNIEPPENVEWSGAEASMFRVLIGTYYDNFCAIARLIGTKTCRQVYEFRVKESSIIAPA
PAEDVDTPPRKKKRKHRLWAAHCRKIQLKKDGSSNHVYNYQPCDHPRQPCDSSCPCVIAQ
NFCEKFCQCSSECQNRFPGCRCKAQCNTKQCPCYLAVRECDPDLCLTCGAADHWDSKNVS
CKNCSIQRGSKKHLLLAPSDVAGWGIFIKDPVQKNEFISEFCGEIISQDEADRRGKVYDK
YMCSFLFNLNNDFVVDATRKGNKIRFANHSVNPNCYAKVMMVNGDHRIGIFAKRAIQTGE
ELFFDYRYSQADALKYVGIEREMEIP

BDBM172164

n/a

Name

BDBM172164

Synonyms:

US10155002, Compound 172 | US11052093, Compound 172 | US9090562, 172

Type

Small organic molecule

Emp. Form.

C35H49N7O2

Mol. Mass.

599.8093

SMILES

CCN([C@H]1CC[C@@H](CC1)N(C)C)c1cc(cc(C(=O)NCc2c(C)cc(C)[nH]c2=O)c1C)-c1ccc(nc1)N1CCNCC1 |r,wU:3.2,wD:6.9,(2.7,8,;1.93,6.67,;2.7,5.33,;4.24,5.33,;5.01,6.67,;6.55,6.67,;7.32,5.33,;6.55,4,;5.01,4,;8.86,5.33,;9.63,6.67,;9.63,4,;1.93,4,;.39,4,;-.38,2.67,;.39,1.33,;1.93,1.33,;2.7,,;4.24,,;1.93,-1.33,;2.7,-2.67,;1.93,-4,;2.7,-5.33,;4.24,-5.33,;1.93,-6.67,;.39,-6.67,;-.38,-8,;-.38,-5.33,;.39,-4,;-.38,-2.67,;2.7,2.67,;4.24,2.67,;-1.92,2.67,;-2.69,4,;-4.23,4,;-5,2.67,;-4.23,1.33,;-2.69,1.33,;-6.54,2.67,;-7.32,4,;-8.86,4,;-9.63,2.67,;-8.86,1.33,;-7.32,1.33,)|

Structure